Gene
ercc1
- ID
- ZDB-GENE-040426-2606
- Name
- excision repair cross-complementation group 1
- Symbol
- ercc1 Nomenclature History
- Previous Names
-
- zgc:77511
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in UV-damage excision repair and mitotic recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zaksauskaite et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cerebrooculofacioskeletal syndrome 4 | Alliance | Cerebrooculofacioskeletal syndrome 4 | 610758 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | ERCC1-like, central domain | ERCC1/RAD10/SWI10 family | Restriction endonuclease type II-like | RuvA domain 2-like |
---|---|---|---|---|---|---|
UniProtKB:Q6NY87 | InterPro | 342 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-165B19 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77511 | ZFIN Curated Data | |
Encodes | cDNA | MGC:171386 | ZFIN Curated Data | |
Encodes | cDNA | MGC:173912 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001103138 (1) | 1399 nt | ||
Genomic | GenBank:BX571724 (1) | 174709 nt | ||
Polypeptide | UniProtKB:Q6NY87 (1) | 342 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | ERCC1 | 19 | Amino acid sequence comparison (1) |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Zaksauskaite, R., Thomas, R.C., van Eeden, F., El-Khamisy, S.F. (2021) Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Science advances. 7(5):
- Kim, Y., Jeong, J., Chatterjee, N., Yim, U.H., Kwon, J.H., Park, M.S., Choi, J. (2019) Activation of the nucleotide excision repair pathway by crude oil exposure: A translational study from model organisms to the Hebei Spirit Oil Spill Cohort. Environmental pollution (Barking, Essex : 1987). 254:112997
- Kim, Y., Jeong, J., Lee, S., Choi, I., Choi, J. (2019) Identification of adverse outcome pathway related to high-density polyethylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study. Journal of hazardous materials. 388:121725
- Martins, M., Silva, A., Costa, M.H., Miguel, C., Costa, P.M. (2018) Co-exposure to environmental carcinogens in vivo induces neoplasia-related hallmarks in low-genotoxicity events, even after removal of insult. Scientific Reports. 8:3649
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Aanes, H., Winata, C., Moen, L.F., Østrup, O., Mathavan, S., Collas, P., Rognes, T., and Aleström, P. (2014) Normalization of RNA-sequencing data from samples with varying mRNA levels. PLoS One. 9(2):e89158
- Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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