Gene

ercc1

ID
ZDB-GENE-040426-2606
Name
excision repair cross-complementation group 1
Symbol
ercc1 Nomenclature History
Previous Names
  • zgc:77511
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in UV-damage excision repair and mitotic recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of ERCC4-ERCC1 complex and nucleotide-excision repair factor 1 complex. Human ortholog(s) of this gene implicated in several diseases, including azoospermia; carcinoma (multiple); cerebrooculofacioskeletal syndrome 4; gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zaksauskaite et al., 2021
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
kh4Allele with one deletionExon 2FrameshiftCRISPR
kh5Allele with one deletionExon 2FrameshiftCRISPR
sa14547Allele with one point mutationUnknownPremature StopENU
1 - 3 of 3
Show
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-ercc1Shin et al., 2021
1 - 1 of 1
Show
Human Disease
Associated With ercc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cerebrooculofacioskeletal syndrome 4 Alliance Cerebrooculofacioskeletal syndrome 4 610758
1 - 1 of 1
Associated With ercc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR047260 ERCC1-like, central domain
Family IPR004579 ERCC1/RAD10/SWI10 family
Homologous_superfamily IPR010994 RuvA domain 2-like
Homologous_superfamily IPR011335 Restriction endonuclease type II-like
1 - 4 of 4
Domain Details Per Protein
Protein Additional Resources Length ERCC1-like, central domain ERCC1/RAD10/SWI10 family Restriction endonuclease type II-like RuvA domain 2-like
UniProtKB:Q6NY87 InterPro 342
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 9
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ercc1-201 (1) Ensembl 1,384 nt
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-165B19ZFIN Curated Data
EncodescDNAMGC:77511ZFIN Curated Data
EncodescDNAMGC:171386ZFIN Curated Data
EncodescDNAMGC:173912ZFIN Curated Data
1 - 4 of 4
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanERCC119
Amino acid sequence comparison (1)
Citations
1 - 9 of 9
Show