Gene
lta4h
- ID
- ZDB-GENE-040426-2477
- Name
- leukotriene A4 hydrolase
- Symbol
- lta4h Nomenclature History
- Previous Names
-
- zgc:85809
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable aminopeptidase activity; epoxide hydrolase activity; and leukotriene-A4 hydrolase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; neutrophil chemotaxis; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in intestinal bulb; macrophage; and neutrophil. Orthologous to human LTA4H (leukotriene A4 hydrolase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148006 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR014782 | Peptidase M1, membrane alanine aminopeptidase |
| Domain | IPR015211 | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal |
| Domain | IPR045357 | Aminopeptidase N-like , N-terminal domain |
| Domain | IPR049980 | Leukotriene A4 hydrolase-like, catalytic domain |
| Family | IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aminopeptidase, leukotriene A4 hydrolase-like | Aminopeptidase N-like , N-terminal domain | Aminopeptidase N-like , N-terminal domain superfamliy | Armadillo-type fold | Leukotriene A4 hydrolase/leucine aminopeptidase | Leukotriene A4 hydrolase-like, catalytic domain | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily | Peptidase M1, membrane alanine aminopeptidase | Peptidase M4/M1, CTD superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NUX4 | InterPro | 611 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Liu, D., Jiang, Z., Deng, L., Li, H., Jiang, H. (2023) Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Annals of the New York Academy of Sciences. 1526(1):114-125
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Di Chiacchio, I.M., Gómez-Abenza, E., Paiva, I.M., de Abreu, D.J.M., Rodríguez-Vidal, J.F., Carvalho, E.E.N., Carvalho, S.M., Solis-Murgas, L.D., Mulero, V. (2022) Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development. Scientific Reports. 12:9998
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Isles, H.M., Loynes, C.A., Alasmari, S., Kon, F.C., Henry, K.M., Kadochnikova, A., Hales, J., Muir, C.F., Keightley, M.C., Kadirkamanathan, V., Hamilton, N., Lieschke, G.J., Renshaw, S.A., Elks, P.M. (2021) Pioneer neutrophils release chromatin within in vivo swarms. eLIFE. 10:
- Poplimont, H., Georgantzoglou, A., Boulch, M., Walker, H.A., Coombs, C., Papaleonidopoulou, F., Sarris, M. (2020) Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. Current biology : CB. 30(14):2761-2776.e7
- Qiu, W., Liu, X., Yang, F., Li, R., Xiong, Y., Fu, C., Li, G., Liu, S., Zheng, C. (2020) Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. The Science of the total environment. 716:137062
- LeBert, D., Squirrell, J.M., Freisinger, C., Rindy, J., Golenberg, N., Frecentes, G., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2018) Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.. eLIFE. 7:e30703
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Mazon-Moya, M.J., Willis, A.R., Torraca, V., Boucontet, L., Shenoy, A.R., Colucci-Guyon, E., Mostowy, S. (2017) Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLoS pathogens. 13:e1006467
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