ZFIN is now using GRCz12tu for Genomic Data
Gene
dpydb
- ID
- ZDB-GENE-040426-2459
- Name
- dihydropyrimidine dehydrogenase b
- Symbol
- dpydb Nomenclature History
- Previous Names
-
- dpyd
- zgc:77205 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymine catabolic process and uracil catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestinal bulb; liver; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including acquired thrombocytopenia; acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; neutropenia; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77205 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dihydropyrimidine dehydrogenase deficiency | Alliance | 5-fluorouracil toxicity | 274270 |
| dihydropyrimidine dehydrogenase deficiency | Alliance | Dihydropyrimidine dehydrogenase deficiency | 274270 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| Domain | IPR005720 | Dihydroorotate dehydrogenase, catalytic |
| Domain | IPR017896 | 4Fe-4S ferredoxin-type, iron-sulphur binding domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR028261 | Dihydroprymidine dehydrogenase domain II |
| Homologous_superfamily | IPR009051 | Alpha-helical ferredoxin |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site | 4Fe-4S ferredoxin-type, iron-sulphur binding domain | Aldolase-type TIM barrel | Alpha-helical ferredoxin | Dihydroorotate dehydrogenase, catalytic | Dihydroprymidine dehydrogenase domain II | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NYG8 | InterPro | 1022 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers