Gene
hnrnpul1
- ID
- ZDB-GENE-040426-2432
- Name
- heterogeneous nuclear ribonucleoprotein U-like 1
- Symbol
- hnrnpul1 Nomenclature History
- Previous Names
-
- hnrpul1 (1)
- wu:fb53d10
- wu:fk45c03
- zgc:85971
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within alternative mRNA splicing, via spliceosome; pectoral fin development; and tendon development. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85971 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Blackwell et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ca53 | Allele with one insertion | Exon 12 | Unknown | CRISPR | |
| ca54 | Allele with one insertion | Exon 12 | Unknown | CRISPR | |
| sa705 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23344 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36693 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | Concanavalin A-like lectin/glucanase domain superfamily | Heterogeneous nuclear ribonucleoprotein U, SPRY domain | P-loop containing nucleoside triphosphate hydrolase | SAP domain | SAP domain superfamily | SPRY domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NUT5 | InterPro | 784 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hnrnpul1-201
(1)
|
Ensembl | 3,219 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-12O15 | ZFIN Curated Data | |
| Encodes | EST | fb53d10 | ZFIN Curated Data | |
| Encodes | EST | fk45c03 | ZFIN Curated Data | |
| Encodes | EST | fc04h08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85971 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213271 (1) | 3274 nt | ||
| Genomic | GenBank:CR377223 (2) | 211465 nt | ||
| Polypeptide | UniProtKB:Q6NUT5 (1) | 784 aa |
- Blackwell, D.L., Fraser, S.D., Caluseriu, O., Vivori, C., Tyndall, A.V., Lamont, R.E., Parboosingh, J.S., Innes, A.M., Bernier, F.P., Childs, S.J. (2022) Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3 (Bethesda). 12(5):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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