Gene

helz

ID
ZDB-GENE-040426-2419
Name
helicase with zinc finger
Symbol
helz Nomenclature History
Previous Names
  • wu:fd51f08
  • zgc:77407
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be active in P granule and cytosol. Is expressed in telencephalon. Orthologous to human HELZ (helicase with zinc finger).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Diotel et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa1241Allele with one point mutationUnknownSplice SiteENU
sa14608Allele with one point mutationUnknownSplice SiteENU
sa15507Allele with one point mutationUnknownSplice SiteENU
sa17927Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With helz Human Ortholog
No data available
Associated With helz Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000571 Zinc finger, CCCH-type
Domain IPR011539 Rel homology domain, DNA-binding domain
Domain IPR041677 DNA2/NAM7 helicase, helicase domain
Domain IPR041679 DNA2/NAM7 helicase-like, C-terminal
Domain IPR047187 Upf1-like, C-terminal helicase domain
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Domain Details Per Protein
Protein Additional Resources Length DNA2/NAM7 helicase, helicase domain DNA2/NAM7 helicase-like, C-terminal DNA2/NAM7-like helicase Helicase with zinc finger, DEAD-box 1 P-loop containing nucleoside triphosphate hydrolase Rel homology domain, DNA-binding domain Upf1-like, C-terminal helicase domain Zinc finger, CCCH-type Zinc finger, CCCH-type superfamily
UniProtKB:A0A8M9PFR0 InterPro 1864
UniProtKB:Q6NYU2 InterPro 1860
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA helz-201 (1) Ensembl 6,166 nt
mRNA helz-202 (1) Ensembl 5,880 nt
ncRNA helz-002 (1) Ensembl 938 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-68A10ZFIN Curated Data
Contained inFosmidCH1073-120P15ZFIN Curated Data
EncodesESTfd51f08ZFIN Curated Data
EncodescDNAMGC:77407ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanHELZ17
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseHelz11
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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