Gene
pabpn1
- ID
- ZDB-GENE-040426-2401
- Name
- poly(A) binding protein, nuclear 1
- Symbol
- pabpn1 Nomenclature History
- Previous Names
-
- fb19c03
- wu:fb17e03
- wu:fb18c06
- wu:fb19c03
- zgc:85979
- zgc:92452
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable poly(A) binding activity. Predicted to act upstream of or within mRNA processing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85979 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oculopharyngeal muscular dystrophy | Alliance | Oculopharyngeal muscular dystrophy | 164300 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|
| UniProtKB:A7YYD9 | InterPro | 232 | |||
| UniProtKB:Q6NUT4 | InterPro | 284 | |||
| UniProtKB:A0A8M2B9U2 | InterPro | 228 | |||
| UniProtKB:A0AB32TGH7 | InterPro | 176 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pabpn1-201
(1)
|
Ensembl | 1,737 nt | ||
| mRNA |
pabpn1-202
(1)
|
Ensembl | 2,661 nt | ||
| mRNA |
pabpn1-203
(1)
|
Ensembl | 2,289 nt | ||
| mRNA |
pabpn1-204
(1)
|
Ensembl | 843 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-73G8 | ZFIN Curated Data | |
| Encodes | EST | fb17e03 | ZFIN Curated Data | |
| Encodes | EST | fb18c06 | ZFIN Curated Data | |
| Encodes | EST | fb19c03 | ||
| Encodes | cDNA | MGC:85979 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92452 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171884 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173800 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191819 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105132 (1) | 2669 nt | ||
| Genomic | GenBank:BX294113 (2) | 199820 nt | ||
| Polypeptide | UniProtKB:Q6NUT4 (1) | 284 aa |
- Despic, V., Dejung, M., Gu, M., Krishnan, J., Zhang, J., Herzel, L., Straube, K., Gerstein, M.B., Butter, F., Neugebauer, K.M. (2017) Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Genome research. 27(7):1184-1194
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32
- Steffen, L.S., Guyon, J.R., Vogel, E.D., Beltre, R., Pusack, T.J., Zhou, Y., Zon, L.I., and Kunkel, L.M. (2007) Zebrafish orthologs of human muscular dystrophy genes. BMC Genomics. 8(1):79
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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