Gene
cbwd
- ID
- ZDB-GENE-040426-2388
- Name
- COBW domain containing
- Symbol
- cbwd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables GTPase activity and zinc chaperone activity. Involved in intracellular zinc ion homeostasis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to several human genes including ZNG1C (Zn regulated GTPase metalloprotein activator 1C); ZNG1E (Zn regulated GTPase metalloprotein activator 1E); and ZNG1F (Zn regulated GTPase metalloprotein activator 1F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6897687 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Weiss et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016342Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026487Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026489Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026490Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026491Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026492Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa27234 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44690 | Allele with one point mutation | Unknown | Unknown | ENU | |
| vu1 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| vu2 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003495 | CobW/HypB/UreG, nucleotide-binding domain |
| Domain | IPR011629 | Zinc chaperone CobW-like, C-terminal |
| Family | IPR051316 | Zinc-regulated GTPase metalloprotein activator |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036627 | CobW-like, C-terminal domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CobW/HypB/UreG, nucleotide-binding domain | CobW-like, C-terminal domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Zinc chaperone CobW-like, C-terminal | Zinc-regulated GTPase metalloprotein activator |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0R0B1 | InterPro | 366 | |||||
| UniProtKB:A0AB32TYG4 | InterPro | 366 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-91M11 | ZFIN Curated Data | |
| Encodes | EST | fb76b04 | ||
| Encodes | EST | IMAGE:6897687 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:77617 | ZFIN Curated Data | |
| Has Artifact | EST | fc73a04 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213253 (1) | 1664 nt | ||
| Genomic | GenBank:AL845168 (1) | 198627 nt | ||
| Polypeptide | UniProtKB:A0AB32TYG4 (1) | 366 aa |
No data available
- Weiss, A., Murdoch, C.C., Edmonds, K.A., Jordan, M.R., Monteith, A.J., Perera, Y.R., Rodríguez Nassif, A.M., Petoletti, A.M., Beavers, W.N., Munneke, M.J., Drury, S.L., Krystofiak, E.S., Thalluri, K., Wu, H., Kruse, A.R.S., DiMarchi, R.D., Caprioli, R.M., Spraggins, J.M., Chazin, W.J., Giedroc, D.P., Skaar, E.P. (2022) Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell. 185(12):2148-2163.e27
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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