Gene
csnk1db
- ID
- ZDB-GENE-040426-2385
- Name
- casein kinase 1, delta b
- Symbol
- csnk1db Nomenclature History
- Previous Names
-
- csnk1d
- wu:fb69b03
- wu:fj97a05
- zgc:77627
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including non-motile cilium assembly; positive regulation of canonical Wnt signaling pathway; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and protein phosphorylation. Predicted to be active in cytoplasm; nucleus; and spindle microtubule. Is expressed in several structures, including axis; brain; notochord; presumptive neural retina; and yolk syncytial layer. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome 2. Orthologous to human CSNK1D (casein kinase 1 delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77627 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa35337 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-csnk1db | Kroll et al., 2021 | |
CRISPR2-csnk1db | Kroll et al., 2021 | |
CRISPR3-csnk1db | Kroll et al., 2021 | |
MO1-csnk1db | N/A | Meier et al., 2023 |
1 - 4 of 4
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
advanced sleep phase syndrome 2 | Alliance | Advanced sleep-phase syndrome, familial, 2 | 615224 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Family | IPR050235 | Casein Kinase 1 Ser/Thr Protein Kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
1 - 5 of 5
Domain Details Per Protein
Protein | Additional Resources | Length | Casein Kinase 1 Ser/Thr Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|
UniProtKB:Q6P3K7 | InterPro | 409 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
csnk1db-201
(1)
|
Ensembl | 3,081 nt | ||
mRNA |
csnk1db-202
(1)
|
Ensembl | 1,257 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-105J12 | ZFIN Curated Data | |
Encodes | EST | fb69b03 | ZFIN Curated Data | |
Encodes | EST | fj97a05 | ZFIN Curated Data | |
Encodes | EST | fc48c05 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77627 | ZFIN Curated Data | |
Encodes | cDNA | MGC:113966 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192649 | ZFIN Curated Data |
1 - 7 of 7
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_213250 (1) | 3093 nt | ||
Genomic | GenBank:CR932358 (1) | 138570 nt | ||
Polypeptide | UniProtKB:Q6P3K7 (1) | 409 aa |
- Meier, L., Gahr, B.M., Roth, A., Gihring, A., Kirschner, S., Woitaske-Proske, C., Baier, J., Peifer, C., Just, S., Knippschild, U. (2023) Zebrafish as model system for the biological characterization of CK1 inhibitors. Frontiers in pharmacology. 14:12452461245246
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Kroll, F., Powell, G.T., Ghosh, M., Gestri, G., Antinucci, P., Hearn, T.J., Tunbak, H., Lim, S., Dennis, H.W., Fernandez, J.M., Whitmore, D., Dreosti, E., Wilson, S.W., Hoffman, E.J., Rihel, J. (2021) A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. eLIFE. 10:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Toloza-Villalobos, J., Arroyo, J.I., Opazo, J.C. (2015) The Circadian Clock of Teleost Fish: A Comparative Analysis Reveals Distinct Fates for Duplicated Genes. Journal of molecular evolution. 80(1):57-64
- Smadja Storz, S., Tovin, A., Mracek, P., Alon, S., Foulkes, N.S., and Gothilf, Y. (2013) Casein kinase 1delta activity: a key element in the zebrafish circadian timing system. PLoS One. 8(1):e54189
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
- Albornoz, A., Yáñez, J.M., Foerster, C., Aguirre, C., Pereiro, L., Burzio, V., Moraga, M., Reyes, A.E., and Antonelli, M. (2007) The CK1 gene family: expression patterning in zebrafish development. Biological research. 40(2):251-266
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
1 - 10 of 12
Show