Gene
mettl14
- ID
- ZDB-GENE-040426-2328
- Name
- methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
- Symbol
- mettl14 Nomenclature History
- Previous Names
-
- zgc:77296 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable S-adenosyl-L-methionine binding activity; mRNA binding activity; and mRNA m(6)A methyltransferase activity. Predicted to be involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Predicted to act upstream of or within cell differentiation. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Is expressed in hypural. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77296 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
gyf16 | Allele with one delins | Exon 6 | Unknown | not specified | |
sa12796 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
syu201 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
zko388a | Allele with one deletion | Unknown | Unknown | CRISPR | |
zko388b | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | MT-A70-like | N6-adenosine-methyltransferase non-catalytic subunit METTL14-like | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
---|---|---|---|---|---|
UniProtKB:Q6NZ22 | InterPro | 455 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
mettl14-201
(1)
|
Ensembl | 1,714 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-195F22 | ZFIN Curated Data | |
Contained in | BAC | CH211-201G8 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77296 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_207071 (1) | 1730 nt | ||
Genomic | GenBank:BX119979 (2) | 194023 nt | ||
Polypeptide | UniProtKB:Q6NZ22 (1) | 455 aa |
- Huang, L., Liang, H., Wang, S., Chen, S. (2021) m6A writer complex promotes timely differentiation and survival of retinal progenitor cells in zebrafish. Biochemical and Biophysical Research Communications. 567:171-176
- Anderson, R.A., Schwalbach, K.T., Mui, S.R., LeClair, E.E., Topczewska, J.M., Topczewski, J. (2020) Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency. Disease models & mechanisms. 13(6):
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Sun, L., Ling, Y., Jiang, J., Wang, D., Wang, J., Li, J., Wang, X., Wang, H. (2020) Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq. Chemosphere. 251:126318
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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