Gene

mettl14

ID
ZDB-GENE-040426-2328
Name
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
Symbol
mettl14 Nomenclature History
Previous Names
  • zgc:77296 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable S-adenosyl-L-methionine binding activity; mRNA binding activity; and mRNA m(6)A methyltransferase activity. Predicted to be involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Predicted to act upstream of or within cell differentiation. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Is expressed in hypural. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
gyf16Allele with one delinsExon 6Unknownnot specified
sa12796Allele with one point mutationUnknownPremature StopENU
syu201Allele with one deletionExon 2UnknownCRISPR
zko388aAllele with one deletionUnknownUnknownCRISPR
zko388bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Human Disease
Associated With mettl14 Human Ortholog
No data available
Associated With mettl14 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR007757 MT-A70-like
Family IPR045123 N6-adenosine-methyltransferase non-catalytic subunit METTL14-like
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
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Domain Details Per Protein
Protein Additional Resources Length MT-A70-like N6-adenosine-methyltransferase non-catalytic subunit METTL14-like S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:Q6NZ22 InterPro 455
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA mettl14-201 (1) Ensembl 1,714 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-195F22ZFIN Curated Data
Contained inBACCH211-201G8ZFIN Curated Data
EncodescDNAMGC:77296ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanMETTL144
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseMettl143
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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