Gene

eif5a

ID

ZDB-GENE-040426-2229

Name

eukaryotic translation initiation factor 5A

Symbol

eif5a Nomenclature History

Previous Names

wu:fb17e01
wu:fb63h04
wu:fk81e04
zgc:77099

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Is expressed in endoderm; intestine; liver; pancreas; and swim bladder. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6909077 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Faundes-Banka syndrome	619376

Associated With eif5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR020189	Translation elongation factor, IF5A C-terminal
Domain	IPR048670	Translation initiation factor 5A-like, N-terminal
Family	IPR001884	Translation elongation factor IF5A-like
Homologous_superfamily	IPR008991	Translation protein SH3-like domain superfamily
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR014722	Large ribosomal subunit protein uL2, domain 2
PTM	IPR019769	Translation elongation factor, IF5A, hypusine site

Domain Details Per Protein

Protein	Length	Large ribosomal subunit protein uL2, domain 2	Nucleic acid-binding, OB-fold	Translation elongation factor, IF5A C-terminal	Translation elongation factor, IF5A, hypusine site	Translation elongation factor IF5A-like	Translation initiation factor 5A-like, N-terminal	Translation protein SH3-like domain superfamily
UniProtKB:Q6NX89 InterPro PDB	155

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eif5a-201 (1) Ensembl	Havana	1916 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	eif5a-202 (1) Ensembl	Havana	969 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	eif5a-203 (1) Ensembl	Havana	1116 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	eif5a-204 (1) Ensembl	Havana	844 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	eif5a-205 (1) Ensembl	Havana	609 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	eif5a-206 (1) Ensembl	Havana	407 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations