Gene
ywhabb
- ID
- ZDB-GENE-040426-2160
- Name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b
- Symbol
- ywhabb Nomenclature History
- Previous Names
-
- ywhab2
- ywhab
- wu:fb22g04
- wu:fr86a12
- zgc:64092
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in protein localization and signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; liver and biliary system; nervous system; otic vesicle; and tail bud. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64092 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 14-3-3 domain | 14-3-3 domain superfamily | 14-3-3 protein | 14-3-3 protein, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:Q7T356 | InterPro | 242 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ywhabb-201
(1)
|
Ensembl | 1,525 nt | ||
| mRNA |
ywhabb-202
(1)
|
Ensembl | 888 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-316K5 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-81C5 | ZFIN Curated Data | |
| Encodes | EST | fb22g04 | ZFIN Curated Data | |
| Encodes | EST | fr86a12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64092 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213145 (1) | 1455 nt | ||
| Genomic | GenBank:CT009705 | 200808 nt | ||
| Polypeptide | UniProtKB:Q7T356 (1) | 242 aa |
- Biswas, S., Chawda, M., Gudi, R., Bellare, J. (2023) Neuroprotective effects of nanogold-based Ayurveda medicine Suvarna Bhasma against rotenone-induced Parkinson's-like model. Journal of Ayurveda and integrative medicine. 15:100854100854
- Antón-Galindo, E., Dalla Vecchia, E., Orlandi, J.G., Castro, G., Gualda, E.J., Young, A.M.J., Guasch-Piqueras, M., Arenas, C., Herrera-Úbeda, C., Garcia-Fernàndez, J., Aguado, F., Loza-Alvarez, P., Cormand, B., Norton, W.H.J., Fernàndez-Castillo, N. (2022) Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish. Molecular psychiatry. 27(9):3739-3748
- Wang, X., Ren, Y., Li, J., Ji, Z., Chen, F., Wang, X. (2020) Identification of the 14-3-3 β/α-A protein as a novel maternal peptidoglycan-binding protein that protects embryos of zebrafish against bacterial infections. Developmental and comparative immunology. 114:103867
- Cao, J., Tan, X. (2018) Comparative and evolutionary analysis of the 14-3-3 family genes in eleven fishes. Gene. 662:76-82
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Tseng, L.C., Zhang, C., Cheng, C.M., Xu, H., Hsu, C.H., Jiang, Y.J. (2014) New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens. PLoS One. 9:e93394
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
- Besser, J., Bagowski, C.P., Salas-Vidal, E., van Hemert, M.J., Bussmann, J., and Spaink, H.P. (2007) Expression analysis of the family of 14-3-3 proteins in zebrafish development. Gene expression patterns : GEP. 7(4):511-520
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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