Gene

cyb5a

ID

ZDB-GENE-040426-2148

Name

cytochrome b5 type A (microsomal)

Symbol

cyb5a Nomenclature History

Previous Names

wu:fb44a11
zgc:64123

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits heme binding activity. Involved in cellular response to xenobiotic stimulus and oxidation-reduction process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in methemoglobinemia. Is expressed in digestive system; head; immature eye; neural crest; and optic stalk. Orthologous to human CYB5A (cytochrome b5 type A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:64123 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyb5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
methemoglobinemia and ambiguous genitalia	Alliance	Methemoglobinemia and ambiguous genitalia	250790

Associated With cyb5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018506	Cytochrome b5, heme-binding site
Domain	IPR001199	Cytochrome b5-like heme/steroid binding domain
Homologous_superfamily	IPR036400	Cytochrome b5-like heme/steroid binding domain superfamily