Gene
ckmb
- ID
- ZDB-GENE-040426-2128
- Name
- creatine kinase, muscle b
- Symbol
- ckmb Nomenclature History
- Previous Names
-
- ckm3 (1)
- wu:fb55e09
- zgc:64204
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in adaxial cell; head; heart; musculature system; and pectoral fin. Orthologous to human CKM (creatine kinase, M-type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64204 (7 images)
- eu306 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR022415 | ATP:guanido phosphotransferase active site |
| Domain | IPR022413 | ATP:guanido phosphotransferase, N-terminal |
| Domain | IPR022414 | ATP:guanido phosphotransferase, catalytic domain |
| Family | IPR000749 | ATP:guanido phosphotransferase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATP:guanido phosphotransferase | ATP:guanido phosphotransferase active site | ATP:guanido phosphotransferase, catalytic domain | ATP:guanido phosphotransferase, N-terminal | ATP:guanido phosphotransferase, N-terminal domain superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T306 | InterPro | 380 | ||||||
| UniProtKB:A8E5L0 | InterPro | 380 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31M14 | ZFIN Curated Data | |
| Encodes | EST | eu306 | Thisse et al., 2005 | |
| Encodes | EST | fb55e09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64204 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174525 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:92070 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001105683 (1) | 1463 nt | ||
| Genomic | GenBank:CR855332 (1) | 212455 nt | ||
| Polypeptide | UniProtKB:A8E5L0 (1) | 380 aa |
- Zhou, Z.Y., Ma, J., Zhao, W.R., Shi, W.T., Zhang, J., Hu, Y.Y., Yue, M.Y., Zhou, W.L., Yan, H., Tang, J.Y., Wang, Y. (2024) Qiangxinyin formula protects against isoproterenol-induced cardiac hypertrophy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 130:155717155717
- Chu, W.K., Huang, S.C., Chang, C.F., Wu, J.L., Gong, H.Y. (2023) Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics. 14:10292001029200
- Mao, K., Li, X., Chen, Z., Dong, X., Zhangsun, D., Zhu, X., Luo, S. (2022) α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal. Frontiers in pharmacology. 13:802917
- Jiao, Y., Yang, S., Min, G., Zhang, Y., Du, X., Wang, Q. (2019) Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Fish & shellfish immunology. 92:241-248
- Prill, K., Carlisle, C., Stannard, M., Windsor Reid, P.J., Pilgrim, D.B. (2019) Myomesin is part of an integrity pathway that responds to sarcomere damage and disease. PLoS One. 14:e0224206
- Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Del Giacco, L., Binelli, A. (2018) Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 232:603-614
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Li, C., Tan, X.F., Lim, T.K., Lin, Q., Gong, Z. (2016) Comprehensive and quantitative proteomic analyses of zebrafish plasma reveals conserved protein profiles between genders and between zebrafish and human. Scientific Reports. 6:24329
- Carneiro, M., Gutiérrez-Praena, D., Osório, H., Vasconcelos, V., Carvalho, A.P., Campos, A. (2015) Proteomic analysis of anatoxin-a acute toxicity in zebrafish reveals gender specific responses and additional mechanisms of cell stress. Ecotoxicology and environmental safety. 120:93-101
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