Gene
tead1a
- ID
- ZDB-GENE-040426-2101
- Name
- TEA domain family member 1a
- Symbol
- tead1a Nomenclature History
- Previous Names
-
- tead1
- zgc:63696
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; cilium assembly; and determination of heart left/right asymmetry. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in nervous system; neural plate; and somite. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to human TEAD1 (TEA domain transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63696 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Fillatre et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014669Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023162Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa44258 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 3 of 3
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sveinsson chorioretinal atrophy | Alliance | Sveinsson chorioretinal atrophy | 108985 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TEA/ATTS domain | TEA/ATTS domain superfamily | TEC1/TEAD Transcription Factor | Transcriptional enhancer factor, metazoa | YAP binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B730 | InterPro | 422 | |||||
| UniProtKB:Q7SXX3 | InterPro | 393 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tead1a-201
(1)
|
Ensembl | 748 nt | ||
| mRNA |
tead1a-202
(1)
|
Ensembl | 1,744 nt | ||
| ncRNA |
tead1a-003
(1)
|
Ensembl | 817 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(14xUAS:DsRed,MYC-tead1a_Y417H) |
| 1 | Miesfeld et al., 2015 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-166I5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-254K13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63696 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113979 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174255 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191697 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212847 (1) | 1683 nt | ||
| Genomic | GenBank:BX908400 (2) | 136937 nt | ||
| Polypeptide | UniProtKB:A0A8M3B730 (1) | 422 aa |
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Cayuso, J., Xu, Q., Addison, M., Wilkinson, D.G. (2019) Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLIFE. 8:
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Xue, C., Liu, X., Wen, B., Yang, R., Gao, S., Tao, J., Zhou, J. (2019) Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c. Frontiers in cell and developmental biology. 7:277
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liu, J., Merkle, F.T., Gandhi, A.V., Gagnon, J.A., Woods, I.G., Chiu, C.N., Shimogori, T., Schier, A.F., Prober, D.A. (2015) Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development (Cambridge, England). 142(6):1113-24
- Mateus, R., Lourenço, R., Fang, Y., Brito, G., Farinho, A., Valério, F., Jacinto, A. (2015) Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration. Development (Cambridge, England). 142(16):2752-63
- Miesfeld, J.B., Gestri, G., Clark, B.S., Flinn, M.A., Poole, R.J., Bader, J.R., Besharse, J.C., Wilson, S.W., Link, B.A. (2015) Yap and Taz regulate retinal pigment epithelial cell fate. Development (Cambridge, England). 142(17):3021-32
1 - 10 of 15
Show