Gene

pla2g6

ID

ZDB-GENE-040426-2079

Name

phospholipase A2, group VI (cytosolic, calcium-independent)

Symbol

pla2g6 Nomenclature History

Previous Names

wu:fc06g09 (1)
zgc:77476

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have hydrolase activity. Predicted to be involved in lipid catabolic process. Is expressed in brain. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Sánchez et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pla2g6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodegeneration with brain iron accumulation 2a	Alliance	Infantile neuroaxonal dystrophy 1	256600
neurodegeneration with brain iron accumulation 2b	Alliance	Neurodegeneration with brain iron accumulation 2B	610217
Parkinson's disease 14	Alliance	Parkinson disease 14, autosomal recessive	612953

Associated With pla2g6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002641	Patatin-like phospholipase domain
Homologous_superfamily	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Acyl transferase/acyl hydrolase/lysophospholipase	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Patatin-like phospholipase domain
UniProtKB:H0WEI5 InterPro	151
UniProtKB:A0A286Y8H5 InterPro	793
UniProtKB:A0A2R8RYP7 InterPro	824
UniProtKB:Q1LWE7 InterPro	210
UniProtKB:H0WE43 InterPro	824
UniProtKB:F1QXU0 InterPro	818
UniProtKB:H0WEP7 InterPro	291
UniProtKB:Q6NWY0 InterPro	818
UniProtKB:Q1LWA7 InterPro	818

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	pla2g6-202 (1) Ensembl	873 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pla2g6-203 (1) Ensembl	3830 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pla2g6-204 (1) Ensembl	549 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations