Gene

glrx5

ID
ZDB-GENE-040426-1957
Name
glutaredoxin 5 homolog (S. cerevisiae)
Symbol
glrx5 Nomenclature History
Previous Names
  • grx5 (1)
  • glutaredoxin 5
  • id:ibd5119 (1)
  • shiraz
  • shz
  • wu:fa09g08
  • zgc:73343
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Is predicted to enable 2 iron, 2 sulfur cluster binding activity; metal ion binding activity; and protein-disulfide reductase activity. Acts upstream of or within hemopoiesis and iron-sulfur cluster assembly. Located in mitochondrion. Is expressed in cardiovascular system; immature eye; intermediate cell mass of mesoderm; and liver. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glrx5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive pyridoxine-refractory sideroblastic anemia 3 Alliance Anemia, sideroblastic, 3, pyridoxine-refractory 616860
Spasticity, childhood-onset, with hyperglycinemia 616859
Associated With glrx5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002109 Glutaredoxin
Domain IPR033658 Glutaredoxin, PICOT-like
Family IPR004480 Monothiol glutaredoxin-related
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Glutaredoxin Glutaredoxin, PICOT-like Monothiol glutaredoxin-related Thioredoxin-like superfamily
UniProtKB:Q6PBM1 155
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations