Gene
lgals2b
- ID
- ZDB-GENE-040426-1590
- Name
- lectin, galactoside-binding, soluble, 2b
- Symbol
- lgals2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable carbohydrate binding activity; galactoside binding activity; and laminin binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be active in extracellular space. Is expressed in digestive system; musculature system; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human LGALS2 (galectin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lgals2b | N/A | Thijssen et al., 2006 |
| MO2-lgals2b | N/A | Thijssen et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Myocardial infarction, susceptibility to} | 608446 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | Galectin, carbohydrate recognition domain | Galectin-like |
|---|---|---|---|---|---|
| UniProtKB:Q7SXJ0 | InterPro | 119 | |||
| UniProtKB:F8W2U6 | InterPro | 132 | |||
| UniProtKB:A0AB32TSX7 | InterPro | 136 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lgals2b-201
(1)
|
Ensembl | 547 nt | ||
| mRNA |
lgals2b-202
(1)
|
Ensembl | 617 nt | ||
| mRNA |
lgals2b-203
(1)
|
Ensembl | 659 nt | ||
| mRNA |
lgals2b-204
(1)
|
Ensembl | 615 nt | ||
| mRNA |
lgals2b-205
(1)
|
Ensembl | 662 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-379F7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66283 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193092 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200514 (1) | 557 nt | ||
| Genomic | GenBank:FP015829 (2) | 96157 nt | ||
| Polypeptide | UniProtKB:A0AB32TSX7 (1) | 136 aa |
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron, V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978
- Siriyappagouder, P., Galindo-Villegas, J., Dhanasiri, A.K.S., Zhang, Q., Mulero, V., Kiron,V., Fernandes, J.M.O. (2020) Pseudozyma Priming Influences Expression of Genes Involved in Metabolic Pathways and Immunity in Zebrafish Larvae. Frontiers in immunology. 11:978
- Huo, X., Li, H., Li, Z., Yan, C., Agrawal, I., Mathavan, S., Liu, J., Gong, Z. (2019) Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Scientific Reports. 9:1509
- Scheldeman, C., Mills, J.D., Siekierska, A., Serra, I., Copmans, D., Iyer, A.M., Whalley, B.J., Maes, J., Jansen, A.C., Lagae, L., Aronica, E., de Witte, P.A.M. (2017) mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis. Neurobiology of disease. 108:225-237
- Xiao, B., Cui, L.Q., Ding, C., Wang, H. (2017) Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Zebrafish. 14(3):209-215
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America. 103(43):15975-15980
- Ahmed, H., Du, S.J., O'Leary, N., and Vasta, G.R. (2004) Biochemical and molecular characterization of galectins from zebrafish (Danio rerio): notochord-specific expression of a prototype galectin during early embryogenesis. Glycobiology. 14(3):219-232
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