ZFIN is now using GRCz12tu for Genomic Data
Gene
muc5.3
- ID
- ZDB-GENE-040426-1562
- Name
- mucin 5.3
- Symbol
- muc5.3 Nomenclature History
- Previous Names
-
- si:ch73-343m12.1
- zgc:66178
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be active in extracellular matrix and extracellular space. Is expressed in esophagus and intestine.
- Genome Resources
- Note
-
This gene is orthologous to BOTH human MUC5AC and MUC5B (evidence: amino acid alignment, phylogenetic tree and synteny) and mouse Muc5ac and Muc5b (amino acid alignment and synteny). The nomenclature was chosen to avoid implying an orthologous relationship to only one of these genes.
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15145 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34250 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34251 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34252 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34253 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41087 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41088 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine knot, C-terminal | Cystine-knot cytokine | Glycoprotein hormone subunit beta | Mucin/von Willebrand/Thrombospondin superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QC84 | InterPro | 3197 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
muc5.3-201
(1)
|
Ensembl | 17,220 nt | ||
| mRNA |
muc5.3-202
(1)
|
Ensembl | 291 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-343M12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-11F16 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:66178 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021477626 (1) | GRCz12tu | 16480 nt | |
| Genomic | GenBank:CU463038 (1) | 109814 nt | ||
| Polypeptide | UniProtKB:A0A8M9QC84 (1) | 3197 aa |
No data available
- An, H.J., Lee, Y.J., Choe, C.P., Cho, H.K., Song, D.H. (2021) Long noncoding RNAs associated with nonalcoholic fatty liver disease in a high cholesterol diet adult zebrafish model. Scientific Reports. 11:23005
- Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):
- Liyanage, T.D., Dahanayake, P.S., Edirisinghe, S.L., Nikapitiya, C., Heo, G.J., De Zoysa, M., Whang, I. (2020) Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation. Molecules. 25(13):
- Rajapaksha, D.C., Edirisinghe, S.L., Nikapitiya, C., Dananjaya, S., Kwun, H.J., Kim, C.H., Oh, C., Kang, D.H., De Zoysa, M. (2020) Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish. Marine drugs. 18(11):
- Ye, L., Bae, M., Cassilly, C.D., Jabba, S.V., Thorpe, D.W., Martin, A.M., Lu, H.Y., Wang, J., Thompson, J.D., Lickwar, C.R., Poss, K.D., Keating, D.J., Jordt, S.E., Clardy, J., Liddle, R.A., Rawls, J.F. (2020) Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host & Microbe. 29(2):179-196.e9
- Edirisinghe, S.L., Dananjaya, S.H.S., Nikapitiya, C., Liyanage, T.D., Lee, K.A., Oh, C., Kang, D.H., De Zoysa, M. (2019) Novel pectin isolated from Spirulina maxima enhances the disease resistance and immune responses in zebrafish against Edwardsiella piscicida and Aeromonas hydrophila. Fish & shellfish immunology. 94:558-565
- Udayangani, R.M.C., Dananjaya, S.H.S., Nikapitiya, C., Heo, G.J., Lee, J., De Zoysa, M. (2017) Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish & shellfish immunology. 66:173-184
- Lang, T., Klasson, S., Larsson, E., Johansson, M.E., Hansson, G.C., Samuelsson, T. (2016) Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP. Molecular Biology and Evolution. 33(8):1921-36
- Jevtov, I., Samuelsson, T., Yao, G., Amsterdam, A., Ribbeck, K. (2014) Zebrafish as a model to study live mucus physiology. Scientific Reports. 4:6653
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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