ZFIN is now using GRCz12tu for Genomic Data
Gene
prmt7
- ID
- ZDB-GENE-040426-1560
- Name
- protein arginine methyltransferase 7
- Symbol
- prmt7 Nomenclature History
- Previous Names
-
- zgc:66172
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Acts upstream of with a negative effect on defense response to virus. Acts upstream of or within with a positive effect on cytoskeleton organization. Predicted to be located in cytosol and nucleus. Is expressed in adaxial cell; brain; eye; otic vesicle; and somite. Orthologous to human PRMT7 (protein arginine methyltransferase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66172 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihbp4 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihbp7 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa552 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38029 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44256 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Short stature, brachydactyly, intellectual developmental disability, and seizures | 617157 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR055135 | Protein arginine N-methyltransferase domain |
| Family | IPR014644 | Protein arginine N-methyltransferase PRMT7 |
| Family | IPR025799 | Protein arginine N-methyltransferase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
1 - 4 of 4
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein arginine N-methyltransferase | Protein arginine N-methyltransferase domain | Protein arginine N-methyltransferase PRMT7 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A2AV36 | InterPro | 683 | ||||
| UniProtKB:A0A8M6YVX1 | InterPro | 550 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51L3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66172 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191898 | ZFIN Curated Data |
1 - 3 of 3
Show
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200503 (1) | 2526 nt | ||
| Genomic | GenBank:CR383674 (1) | 212086 nt | ||
| Polypeptide | UniProtKB:A2AV36 (1) | 683 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Zhu, J., Liu, X., Cai, X., Ouyang, G., Fan, S., Wang, J., Xiao, W. (2020) Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:988-1000
- Zhang, W., Zhang, Y., Li, S., Wu, Z., Yan, Y., Li, Y. (2018) Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin. Acta biochimica et biophysica Sinica. 50(12):1280-1287
- Zhang, W.W., Zhang, Y.B., Zhao, X.X., Hua, Y., Wu, Z.L., Yan, Y.C., Li, Y.P. (2015) Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton. Journal of molecular cell biology. 7:489-91
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Dong, C.W., Zhang, Y.B., Lu, A.J., Zhu, R., Zhang, F.T., Zhang, Q.Y., and Gui, J.F. (2007) Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish & shellfish immunology. 22(4):380-393
- Hung, C.M., and Li, C. (2004) Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Gene. 340(2):179-187
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show