Gene
prmt7
- ID
- ZDB-GENE-040426-1560
- Name
- protein arginine methyltransferase 7
- Symbol
- prmt7 Nomenclature History
- Previous Names
-
- zgc:66172
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable histone H4R3 methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Acts upstream of with a negative effect on defense response to virus. Acts upstream of or within with a positive effect on cytoskeleton organization. Acts upstream of or within epiboly involved in gastrulation with mouth forming second. Predicted to be located in cytosol and nucleus. Is expressed in adaxial cell; brain; eye; otic vesicle; and somite. Orthologous to human PRMT7 (protein arginine methyltransferase 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66172 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihbp4 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihbp7 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa552 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38029 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44256 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Short stature, brachydactyly, intellectual developmental disability, and seizures | 617157 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR055135 | Protein arginine N-methyltransferase domain |
| Family | IPR014644 | Protein arginine N-methyltransferase PRMT7 |
| Family | IPR025799 | Protein arginine N-methyltransferase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Protein arginine N-methyltransferase | Protein arginine N-methyltransferase domain | Protein arginine N-methyltransferase PRMT7 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A2AV36 | InterPro | 683 | ||||
| UniProtKB:A0A8M6YVX1 | InterPro | 550 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-51L3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66172 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191898 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200503 (1) | 2526 nt | ||
| Genomic | GenBank:CR383674 (1) | 212086 nt | ||
| Polypeptide | UniProtKB:A2AV36 (1) | 683 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Zhu, J., Liu, X., Cai, X., Ouyang, G., Fan, S., Wang, J., Xiao, W. (2020) Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:988-1000
- Zhang, W., Zhang, Y., Li, S., Wu, Z., Yan, Y., Li, Y. (2018) Prmt7 regulates epiboly and gastrulation cell movements by facilitating syntenin. Acta biochimica et biophysica Sinica. 50(12):1280-1287
- Zhang, W.W., Zhang, Y.B., Zhao, X.X., Hua, Y., Wu, Z.L., Yan, Y.C., Li, Y.P. (2015) Prmt7 regulates epiboly by facilitating 2-OST and modulating actin cytoskeleton. Journal of molecular cell biology. 7:489-91
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Dong, C.W., Zhang, Y.B., Lu, A.J., Zhu, R., Zhang, F.T., Zhang, Q.Y., and Gui, J.F. (2007) Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. Fish & shellfish immunology. 22(4):380-393
- Hung, C.M., and Li, C. (2004) Identification and phylogenetic analyses of the protein arginine methyltransferase gene family in fish and ascidians. Gene. 340(2):179-187
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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