Gene
vps28
- ID
- ZDB-GENE-040426-1527
- Name
- VPS28 subunit of ESCRT-I
- Symbol
- vps28 Nomenclature History
- Previous Names
-
- zgc:66078 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within regulation of blood-brain barrier permeability and retina development in camera-type eye. Predicted to be located in endosome. Predicted to be part of ESCRT I complex. Is expressed in eye; neural tube; and pronephric duct. Orthologous to human VPS28 (VPS28 subunit of ESCRT-I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6908738 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-vps28 | Hu et al., 2019 | |
CRISPR2-vps28 | Dong et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR017898 | Vacuolar protein sorting-associated, VPS28, N-terminal |
Domain | IPR017899 | Vacuolar protein sorting-associated, VPS28, C-terminal |
Family | IPR007143 | Vacuolar protein sorting-associated Vps28 |
Homologous_superfamily | IPR037202 | ESCRT assembly domain |
Homologous_superfamily | IPR037206 | VPS28, C-terminal domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | ESCRT assembly domain | Vacuolar protein sorting-associated Vps28 | Vacuolar protein sorting-associated, VPS28, C-terminal | Vacuolar protein sorting-associated, VPS28, N-terminal | VPS28, C-terminal domain superfamily | VPS28, N-terminal domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PH25 | InterPro | 223 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(vps28:EGFP) |
|
| 1 | Dong et al., 2022 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | Fosmid | CH1073-375M16 | ZFIN Curated Data | |
Encodes | EST | IMAGE:6908738 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:66078 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200590 (1) | 1580 nt | ||
Genomic | GenBank:FO704878 (1) | 39966 nt | ||
Polypeptide | UniProtKB:Q6PH25 (1) | 223 aa |
- Dong, X., Jiang, D., Wang, L., Zhao, J., Yu, L., Huang, Y., Wu, X., Zhu, Y., Zhao, Y., Zhao, Q., Zhang, G., Li, X. (2022) VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion. iScience. 25:104042
- Hu, R., Huang, W., Liu, J., Jin, M., Wu, Y., Li, J., Wang, J., Yu, Z., Wang, H., Cao, Y. (2019) Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4):5248-5256
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wu, C.C., Chen, B.S. (2016) A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host-Pathogen Interaction Networks. PLoS One. 11:e0149303
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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