Gene
qki2
- ID
- ZDB-GENE-040426-1462
- Name
- QKI, KH domain containing, RNA binding 2
- Symbol
- qki2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity. Acts upstream of or within skeletal myofibril assembly. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; lateral line system; myotome; and segmental plate. Orthologous to human QKI (QKI, KH domain containing RNA binding).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65890 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa6268 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa9454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa22153 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zf1088 | Allele with one insertion | Exon 4 | Premature Stop | zinc finger nuclease |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | KHDC4/BBP-like, KH-domain type I | KH domain-containing BBP-like | K Homology domain | K Homology domain, type 1 superfamily | Protein quaking, putative nuclear localisation signal | STAR protein, homodimerisation region |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6P104 | InterPro | 319 | ||||||
UniProtKB:A0A8M9QE52 | InterPro | 340 | ||||||
UniProtKB:A0A8M9Q889 | InterPro | 341 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-21E13 | ZFIN Curated Data | |
Encodes | cDNA | MGC:65890 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77340 | ZFIN Curated Data | |
Encodes | cDNA | MGC:175063 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200842 (1) | 1630 nt | ||
Genomic | GenBank:CR678095 (2) | 205015 nt | ||
Polypeptide | UniProtKB:A0A8M9Q889 (1) | 341 aa |
- Bonnet, A., Lambert, G., Ernest, S., Dutrieux, F.X., Coulpier, F., Lemoine, S., Lobbardi, R., Rosa, F.M. (2017) Quaking RNA-Binding Proteins Control Early Myofibril Formation by Modulating Tropomyosin. Developmental Cell. 42(5):527-541.e4
- Radomska, K.J., Sager, J., Farnsworth, B., Tellgren-Roth, Å., Tuveri, G., Peuckert, C., Kettunen, P., Jazin, E., Emilsson, L.S. (2016) Characterization and Expression of the Zebrafish qki Paralogs. PLoS One. 11:e0146155
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kim, S., Kim, J.D., Chung, A.Y., Kim, H.S., Kim, Y.S., Kim, M.J., Koun, S., Lee, Y.M., Rhee, M., Park, H.C., and Huh, T.L. (2012) Antagonistic Regulation of PAF1C and p-TEFb Is Required for Oligodendrocyte Differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(24):8201-8207
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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