Gene

cdkal1

ID

ZDB-GENE-040426-1443

Name

CDK5 regulatory subunit associated protein 1-like 1

Symbol

cdkal1 Nomenclature History

Previous Names

zgc:65864

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have N6-threonylcarbomyladenosine methylthiotransferase activity. Involved in pancreas regeneration and type B pancreatic cell development. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:65864 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from O'Hare et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdkal1 Human Ortholog

No data available

Associated With cdkal1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020612	Methylthiotransferase, conserved site
Domain	IPR002792	TRAM domain
Domain	IPR006638	Elp3/MiaA/NifB-like, radical SAM core domain
Domain	IPR007197	Radical SAM
Domain	IPR013848	Methylthiotransferase, N-terminal
Family	IPR005839	Methylthiotransferase
Family	IPR006466	MiaB-like tRNA modifying enzyme, archaea/eukaryota
Homologous_superfamily	IPR023404	Radical SAM, alpha/beta horseshoe
Homologous_superfamily	IPR038135	Methylthiotransferase, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Elp3/MiaA/NifB-like, radical SAM core domain	Methylthiotransferase	Methylthiotransferase, conserved site	Methylthiotransferase, N-terminal	Methylthiotransferase, N-terminal domain superfamily	MiaB-like tRNA modifying enzyme, archaea/eukaryota	Radical SAM	Radical SAM, alpha/beta horseshoe	TRAM domain
UniProtKB:Q6PG34 InterPro	547

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations