Gene
tmem231
- ID
- ZDB-GENE-040426-1386
- Name
- transmembrane protein 231
- Symbol
- tmem231 Nomenclature History
- Previous Names
-
- chst5
- zgc:64166 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to be involved in cilium assembly; regulation of protein localization; and smoothened signaling pathway. Predicted to act upstream of or within cell projection organization. Predicted to be located in cilium and plasma membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary membrane and ciliary transition zone. Is expressed in blood; median fin fold; and periderm. Human ortholog(s) of this gene implicated in Joubert syndrome 20 and Meckel syndrome. Orthologous to human TMEM231 (transmembrane protein 231).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64166 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la014752Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa6811 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38131 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 3 of 3
Show
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Joubert syndrome 20 | Alliance | Joubert syndrome 20 | 614970 |
Meckel syndrome 11 | 615397 |
1 - 2 of 2
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR019306 | Transmembrane protein 231 |
1 - 1 of 1
Domain Details Per Protein
Protein | Additional Resources | Length | Transmembrane protein 231 |
---|---|---|---|
UniProtKB:Q7T316 | InterPro | 309 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
tmem231-201
(1)
|
Ensembl | 1,631 nt | ||
mRNA |
tmem231-202
(1)
|
Ensembl | 847 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEYP-7F1 | ZFIN Curated Data | |
Encodes | cDNA | MGC:64166 | ZFIN Curated Data |
1 - 2 of 2
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200387 (1) | 1416 nt | ||
Genomic | GenBank:BX890570 (1) | 170260 nt | ||
Polypeptide | UniProtKB:Q7T316 (1) | 309 aa |
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Khatri, D., Putoux, A., Cologne, A., Kaltenbach, S., Besson, A., Bertiaux, E., Guguin, J., Fendler, A., Dupont, M.A., Benoit-Pilven, C., Qebibo, L., Ahmed-Elie, S., Audebert-Bellanger, S., Blanc, P., Rambaud, T., Castelle, M., Cornen, G., Grotto, S., Guët, A., Guibaud, L., Michot, C., Odent, S., Ruaud, L., Sacaze, E., Hamel, V., Bordonné, R., Leutenegger, A.L., Edery, P., Burglen, L., Attié-Bitach, T., Mazoyer, S., Delous, M. (2023) Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 120:e2102569120e2102569120
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 6 of 6
Show