Gene

prkcba

ID

ZDB-GENE-040426-1354

Name

protein kinase C, beta a

Symbol

prkcba Nomenclature History

Previous Names

prkcb1l
zgc:64063 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Is expressed in several structures, including brain; forebrain neural keel; otic placode; pectoral fin musculature; and pronephros. Orthologous to human PRKCB (protein kinase C beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:64063 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkcba Human Ortholog

No data available

Associated With prkcba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000008	C2 domain
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR017892	Protein kinase, C-terminal
Domain	IPR020454	Diacylglycerol/phorbol-ester binding
Family	IPR014375	Protein kinase C, alpha/beta/gamma types
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	C2 domain	C2 domain superfamily	Diacylglycerol/phorbol-ester binding	Protein kinase, ATP binding site	Protein kinase C, alpha/beta/gamma types	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase, C-terminal	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:Q7T2C5 InterPro	668
UniProtKB:A0A8M2BI27 InterPro	667

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	prkcba-201 (1) Ensembl	Havana	2481 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prkcba-202 (1) Ensembl	Havana	1155 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations