Gene
hsd17b3
- ID
- ZDB-GENE-040426-1339
- Name
- hydroxysteroid (17-beta) dehydrogenase 3
- Symbol
- hsd17b3 Nomenclature History
- Previous Names
-
- zgc:64019 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables testosterone 17-beta-dehydrogenase (NADP+) activity. Acts upstream of or within androgen biosynthetic process. Located in endoplasmic reticulum. Is expressed in digestive system; heart; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64019 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| 17-beta hydroxysteroid dehydrogenase 3 deficiency | Alliance | Pseudohermaphroditism, male, with gynecomastia | 264300 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase, conserved site | Short-chain dehydrogenase/reductase SDR | VLCFA Elongation and Steroid Dehydrogenase |
|---|---|---|---|---|---|---|
| UniProtKB:Q6QA32 | InterPro | 307 | ||||
| UniProtKB:Q7T396 | InterPro | 236 | ||||
| UniProtKB:A0AB32TVU7 | InterPro | 306 |
1 - 3 of 3
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsd17b3-201
(1)
|
Ensembl | 2,116 nt | ||
| mRNA |
hsd17b3-203
(1)
|
Ensembl | 2,145 nt | ||
| ncRNA |
hsd17b3-003
(1)
|
Ensembl | 655 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available