Gene
kcnk5b
- ID
- ZDB-GENE-040426-1297
- Name
- potassium channel, subfamily K, member 5b
- Symbol
- kcnk5b Nomenclature History
- Previous Names
-
- kcnk5
- alf
- another longfin
- TASK-2b (1)
- zgc:63921
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables outward rectifier potassium channel activity. Acts upstream of or within fin morphogenesis and regulation of membrane potential. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in fin; gill; heart; integument; and pleuroperitoneal region. Orthologous to human KCNK5 (potassium two pore domain channel subfamily K member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dt30mh | Allele with one point mutation | Unknown | Missense | ENU | |
| j131x8 | Allele with one deletion | Unknown | Frameshift, Premature Stop | g-rays | |
| sa10573 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ty86d | Allele with one point mutation | Unknown | Missense | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Potassium channel domain | Two pore domain potassium channel | Two pore domain potassium channel, TASK family |
|---|---|---|---|---|---|
| UniProtKB:Q6PFU3 | InterPro | 448 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnk5b-201
(1)
|
Ensembl | 2,515 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:kcnk5b-GFP) |
|
| 1 | (2) | |
| Tg(hsp70l:kcnk5b-mCherry) |
|
| 1 | Jiang et al., 2024 | |
| Tg(hsp70l:kcnk5b_S345A-GFP) |
|
| 1 | Yi et al., 2021 | |
| Tg(hsp70l:kcnk5b_S345E-GFP) |
|
| 1 | Yi et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-59D15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7137024 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:63921 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200633 (1) | 2576 nt | ||
| Genomic | GenBank:BX942841 (1) | 202032 nt | ||
| Polypeptide | UniProtKB:Q6PFU3 (1) | 448 aa |
- Jiang, X., Zhao, K., Sun, Y., Song, X., Yi, C., Xiong, T., Wang, S., Yu, Y., Chen, X., Liu, R., Yan, X., Antos, C.L. (2024) The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. PLoS Biology. 22:e3002565e3002565
- Park, S.J., Silic, M.R., Staab, P.L., Chen, J., Zackschewski, E.L., Zhang, G. (2024) Evolution of two-pore domain potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(8):722-749
- Daane, J.M., Blum, N., Lanni, J., Boldt, H., Iovine, M.K., Higdon, C.W., Johnson, S.L., Lovejoy, N.R., Harris, M.P. (2021) Modulation of bioelectric cues in the evolution of flying fishes. Current biology : CB. 31(22):5052-5061.e8
- Yi, C., Spitters, T.W., Al-Far, E.A.A., Wang, S., Xiong, T., Cai, S., Yan, X., Guan, K., Wagner, M., El-Armouche, A., Antos, C.L. (2021) A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription. eLIFE. 10:
- Koudrina, N., Perry, S.F., Gilmour, K.M. (2020) The role of TASK-2 channels in CO2 sensing in zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 319(3):R329-R342
- Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9
- König, D., Dagenais, P., Senk, A., Djonov, V., Aegerter, C.M., Jaźwińska, A. (2019) Distribution and Restoration of Serotonin-Immunoreactive Paraneuronal Cells During Caudal Fin Regeneration in Zebrafish. Frontiers in molecular neuroscience. 12:227
- Lanni, J.S., Peal, D., Ekstrom, L., Chen, H., Stanclift, C., Bowen, M.E., Mercado, A., Gamba, G., Kahle, K.T., Harris, M.P. (2019) Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development. Developmental Biology. 456(2):164-178
- Daane, J.M., Lanni, J., Rothenberg, I., Seebohm, G., Higdon, C.W., Johnson, S.L., Harris, M.P. (2018) Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin. Scientific Reports. 8:10391
- Murciano, C., Cazorla-Vázquez, S., Gutiérrez, J., Hijano, J.A., Ruiz-Sánchez, J., Mesa-Almagro, L., Martín-Reyes, F., Fernández, T.D., Marí-Beffa, M. (2018) Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins. Journal of anatomy. 232(5):783-805
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