ZFIN is now using GRCz12tu for Genomic Data
Gene
foxl1
- ID
- ZDB-GENE-040426-1181
- Name
- forkhead box L1
- Symbol
- foxl1 Nomenclature History
- Previous Names
-
- zgc:63595
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including cartilage morphogenesis; pectoral fin morphogenesis; and regulation of bone mineralization. Predicted to be located in nucleus. Is expressed in several structures, including brain; digestive system; head; pleuroperitoneal region; and presumptive neural retina. Used to study osteoporosis and otosclerosis. Human ortholog(s) of this gene implicated in otosclerosis 11. Orthologous to human FOXL1 (forkhead box L1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| otosclerosis 11 | Alliance | Otosclerosis 11 | 620576 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| otosclerosis | foxl1nfl1/nfl1 (AB) | standard conditions | Hawkey-Noble et al., 2022 |
| osteoporosis | foxl1nfl1/nfl1 (AB) | standard conditions | Hawkey-Noble et al., 2022 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047514 | Forkhead box protein L1, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein L1, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SY22 | InterPro | 363 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers