Gene

pde10a

ID

ZDB-GENE-040426-1115

Name

phosphodiesterase 10A

Symbol

pde10a Nomenclature History

Previous Names

zgc:56689

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have cGMP-stimulated cyclic-nucleotide phosphodiesterase activity. Predicted to be involved in negative regulation of cGMP-mediated signaling. Is expressed in chordo neural hinge; epidermis; nervous system; and notochord. Orthologous to human PDE10A (phosphodiesterase 10A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56689 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Lambert et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde10a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Dyskinesia, limb and orofacial, infantile-onset	616921
		Striatal degeneration, autosomal dominant	616922

Associated With pde10a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003018	GAF domain
Domain	IPR003607	HD/PDEase domain
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR029016	GAF-like domain superfamily
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily