Gene
sh2d3cb
- ID
- ZDB-GENE-040426-1052
- Name
- SH2 domain containing 3Cb
- Symbol
- sh2d3cb Nomenclature History
- Previous Names
-
- sh2d3c
- zgc:56490 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SH2D3C (SH2 domain containing 3C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56490 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000980 | SH2 domain |
Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
Domain | IPR044102 | SHEP1/BCAR3/NSP1, SH2 domain |
Family | IPR051853 | Adapter protein with SH2 and Ras-GEF domains |
Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Adapter protein with SH2 and Ras-GEF domains | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | SH2 domain | SH2 domain superfamily | SHEP1/BCAR3/NSP1, SH2 domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCW0 | InterPro | 629 | |||||||
UniProtKB:Q7ZUD0 | InterPro | 635 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
sh2d3cb-201
(1)
|
Ensembl | 659 nt | ||
mRNA |
sh2d3cb-202
(1)
|
Ensembl | 694 nt | ||
mRNA |
sh2d3cb-203
(1)
|
Ensembl | 2,537 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-233F10 | ZFIN Curated Data | |
Encodes | cDNA | MGC:56490 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201076 (1) | 2577 nt | ||
Genomic | GenBank:BX088597 (1) | 172098 nt | ||
Polypeptide | UniProtKB:Q7ZUD0 (1) | 635 aa |
- Takada, N., and Appel, B. (2010) Identification of genes expressed by zebrafish oligodendrocytes using a differential microarray screen. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2041-2047
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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