Gene
vrk2
- ID
- ZDB-GENE-040426-1046
- Name
- VRK serine/threonine kinase 2
- Symbol
- vrk2 Nomenclature History
- Previous Names
-
- vrk
- zgc:56483
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within aggressive behavior and social behavior. Predicted to be located in membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-vrk2 | Thyme et al., 2019 | |
CRISPR2-vrk2 | Umeda et al., 2022 | |
MO1-vrk2 | N/A | Bagheri et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Family | IPR050235 | Casein Kinase 1 Ser/Thr Protein Kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Casein Kinase 1 Ser/Thr Protein Kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6Z1N2 | InterPro | 486 | |||||
UniProtKB:B8JHS7 | InterPro | 574 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-173F1 | ZFIN Curated Data | |
Encodes | cDNA | MGC:56483 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201170 (1) | 2138 nt | ||
Genomic | GenBank:CR354594 (1) | 196408 nt | ||
Polypeptide | UniProtKB:B8JHS7 (1) | 574 aa |
- Carrasco Apolinario, M.E., Umeda, R., Teranishi, H., Shan, M., Phurpa, ., Sebastian, W.A., Lai, S., Shimizu, N., Shiraishi, H., Shikano, K., Hikida, T., Hanada, T., Ohta, K., Hanada, R. (2023) Behavioral and neurological effects of Vrk1 deficiency in zebrafish. Biochemical and Biophysical Research Communications. 675:101810-18
- Umeda, R., Teranishi, H., Hada, K., Shimizu, N., Shiraishi, H., Urushibata, H., Shaohong, L., Shide, M., Apolinario, M.E.C., Higa, R., Shikano, K., Shin, T., Mimata, H., Hikida, T., Hanada, T., Hanada, R. (2022) Vrk2 deficiency elicits aggressive behavior in female zebrafish. Genes to cells : devoted to molecular & cellular mechanisms. 27(4):254-265
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bagheri, H., Badduke, C., Qiao, Y., Colnaghi, R., Abramowicz, I., Alcantara, D., Dunham, C., Wen, J., Wildin, R.S., Nowaczyk, M.J., Eichmeyer, J., Lehman, A., Maranda, B., Martell, S., Shan, X., Lewis, S.M., O'Driscoll, M., Gregory-Evans, C.Y., Rajcan-Separovic, E. (2016) Identifying candidate genes for 2p15p16.1 microdeletion syndrome using clinical, genomic, and functional analysis. JCI insight. 1:e85461
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Titus, T.A., Selvig, D.R., Qin, B., Wilson, C., Starks, A.M., Roe, B.A., and Postlethwait, J.H. (2006) The Fanconi anemia gene network is conserved from zebrafish to human. Gene. 371(2):211-223
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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