Gene

qars1

ID
ZDB-GENE-040426-1011
Name
glutaminyl-tRNA synthetase 1
Symbol
qars1 Nomenclature History
Previous Names
  • qars
  • zgc:56395
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to localize to aminoacyl-tRNA synthetase multienzyme complex and cytosol. Is expressed in liver. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With qars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Microcephaly, progressive, seizures, and cerebral and cerebellar atrophy 615760
Associated With qars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR007638 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2
Domain IPR007639 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal
Domain IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
Domain IPR020059 Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
Family IPR000924 Glutamyl/glutaminyl-tRNA synthetase
Family IPR004514 Glutamine-tRNA synthetase
Homologous_superfamily IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, N-terminal
Homologous_superfamily IPR042558 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1
Homologous_superfamily IPR042559 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class I, conserved site Glutamine-tRNA synthetase Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 Glutamyl/glutaminyl-tRNA synthetase Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain superfamily Ribosomal protein L25/Gln-tRNA synthetase, N-terminal Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:B0UYD6 774
UniProtKB:Q6DRJ2 774
UniProtKB:B0UYD7 224
UniProtKB:B0UYD5 457
UniProtKB:Q7ZWG7 437
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations