Gene

uros

ID
ZDB-GENE-040323-2
Name
uroporphyrinogen III synthase
Symbol
uros Nomenclature History
Previous Names
  • wu:fd13d11
  • zgc:110240
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in uroporphyrinogen III biosynthetic process. Predicted to act upstream of or within tetrapyrrole biosynthetic process. Predicted to be active in cytosol. Is expressed in hematopoietic system; kidney; mesoderm; and notochord. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la018325TgTransgenic insertionUnknownUnknownDNA
Zebrafish International Resource Center (ZIRC) (order this)
sa35380Allele with one point mutationUnknownSplice SiteENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
1 - 2 of 2
Show
Sequence Targeting Reagents
No data available
Human Disease
Associated With uros Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cutaneous porphyria Alliance Porphyria, congenital erythropoietic 263700
1 - 1 of 1
Associated With uros Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
Family IPR039793 Uroporphyrinogen-III synthase
Homologous_superfamily IPR036108 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Tetrapyrrole biosynthesis, uroporphyrinogen III synthase Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily Uroporphyrinogen-III synthase
UniProtKB:Q568K6 InterPro 262
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA uros-201 (1)
Ensembl
Ensembl 1,859 nt
ZFIN BLAST
mRNA uros-202 (1)
Ensembl
Ensembl 911 nt
ZFIN BLAST
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
ContainsSNPrs3728525
    		ZFIN Curated Data
    EncodesESTfd13d11ZFIN Curated Data
    EncodesESTIMAGE:6912557Thisse et al., 2004
    EncodescDNAMGC:110240ZFIN Curated Data
    EncodescDNAMGC:192012ZFIN Curated Data
    1 - 5 of 5
    Show
    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Citations
    Your Input Welcome
    We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.