Gene
aplp1
- ID
- ZDB-GENE-040319-1
- Name
- amyloid beta (A4) precursor-like protein 1
- Symbol
- aplp1 Nomenclature History
- Previous Names
-
- aplp
- im:7153266
- wu:fj55h01
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable alpha-2A adrenergic receptor binding activity; alpha-2B adrenergic receptor binding activity; and alpha-2C adrenergic receptor binding activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in nervous system. Orthologous to human APLP1 (amyloid beta precursor like protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153266 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aplp1 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019744 | Amyloidogenic glycoprotein, copper-binding domain conserved site |
| Conserved_site | IPR019745 | Amyloidogenic glycoprotein, intracellular domain, conserved site |
| Domain | IPR008154 | Amyloidogenic glycoprotein, extracellular |
| Domain | IPR011178 | Amyloidogenic glycoprotein, copper-binding |
| Domain | IPR015849 | Amyloidogenic glycoprotein, heparin-binding |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Amyloidogenic glycoprotein | Amyloidogenic glycoprotein, copper-binding | Amyloidogenic glycoprotein, copper-binding domain conserved site | Amyloidogenic glycoprotein, copper-binding domain superfamily | Amyloidogenic glycoprotein, E2 domain | Amyloidogenic glycoprotein, extracellular | Amyloidogenic glycoprotein, heparin-binding | Amyloidogenic glycoprotein, heparin-binding domain superfamily | Amyloidogenic glycoprotein, intracellular domain, conserved site | Beta-amyloid precursor protein C-terminal | E2 domain superfamily | PH-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IXG2 | InterPro | 723 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-147F13 | ZFIN Curated Data | |
| Encodes | EST | fj55h01 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7153266 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001342885 (1) | 2776 nt | ||
| Genomic | GenBank:CR848749 (2) | 161648 nt | ||
| Polypeptide | UniProtKB:A0A0R4IXG2 (1) | 723 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Karuppan, S.J., Vogt, A., Fischer, Z., Ladutska, A., Swiastyn, J., McGraw, H.F., Bouyain, S. (2021) Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. The Journal of biological chemistry. 298(2):101541
- Banote, R.K., Chebli, J., Şatır, T.M., Varshney, G.K., Camacho, R., Ledin, J., Burgess, S.M., Abramsson, A., Zetterberg, H. (2020) Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Scientific Reports. 10:10127
- Li, X., Han, Y., Sun, S., Shan, D., Ma, X., He, G., Mergu, N., Park, J.S., Kim, C.H., Son, Y.A. (2020) A diaminomaleonitrile-appended BODIPY chemosensor for the selective detection of Cu2+ via oxidative cyclization and imaging in SiHa cells and zebrafish. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 233:118179
- Hogl, S., van Bebber, F., Dislich, B., Kuhn, P.H., Haass, C., Schmid, B., and Lichtenthaler, S.F. (2013) Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13(9):1519-27
- Liao, H.K., Wang, Y., Watt, K.E., Wen, Q., Breitback, J., Kemmet, C.K., Clark, K.J., Ekker, S.C., Essner, J.J., and McGrail, M. (2012) Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):415-425
- Gomez, G.A., Veldman, M.B., Zhao, Y., Burgess, S., and Lin, S. (2009) Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. PLoS One. 4(3):e4994
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