ZFIN is now using GRCz12tu for Genomic Data
Gene
rtn4r
- ID
- ZDB-GENE-040310-1
- Name
- reticulon 4 receptor
- Symbol
- rtn4r Nomenclature History
- Previous Names
-
- NgR
- Nogo-66 receptor
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within axon guidance and peripheral nervous system neuron axonogenesis. Predicted to be located in membrane raft; perikaryon; and plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92613 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Brösamle et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| schizophrenia | Alliance | {Schizophrenia, susceptibility to} | 181500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Family | IPR050541 | Leucine-rich repeat and transmembrane domain-containing protein |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat and transmembrane domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6X3Y5 | InterPro | 479 | |||||
| UniProtKB:A0AC58JI91 | InterPro | 465 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers