Gene

myf6

ID

ZDB-GENE-040309-2

Name

myogenic factor 6

Symbol

myf6 Nomenclature History

Previous Names

herculin (1)
mrf4 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in skeletal muscle tissue development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in congenital structural myopathy. Is expressed in several structures, including Rohon-Beard neurons; adaxial cell; fin; muscle precursor cell; and musculature system. Orthologous to human MYF6 (myogenic factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

23 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu833 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Wang et al., 2008
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myf6 Human Ortholog

No data available

Associated With myf6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002546	Myogenic muscle-specific protein, N-terminal
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR039704	Myogenic factor
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily