Gene
tlr3
- ID
- ZDB-GENE-040219-7
- Name
- toll-like receptor 3
- Symbol
- tlr3 Nomenclature History
- Previous Names
-
- zgc:123006
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium and response to virus. Predicted to be located in early endosome; endoplasmic reticulum membrane; and endosome membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; liver disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu558 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Graber et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
Domain | IPR041015 | Toll-like receptor 3 trans-membrane domain |
Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
Repeat | IPR001611 | Leucine-rich repeat |
Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor 3 trans-membrane domain |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q32PW5 | InterPro | 903 |
Interactions and Pathways
No data available
Plasmids
No data available