Gene

tlr3

ID

ZDB-GENE-040219-7

Name

toll-like receptor 3

Symbol

tlr3 Nomenclature History

Previous Names

zgc:123006

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium and response to virus. Predicted to be located in early endosome; endoplasmic reticulum membrane; and endosome membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; liver disease (multiple); and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 15 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu558 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Graber et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{HIV1 infection, resistance to}	609423
		{Immunodeficiency 83, susceptibility to viral infections}	613002

Associated With tlr3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Domain	IPR041015	Toll-like receptor 3 trans-membrane domain
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype