Gene
mdh1aa
- ID
- ZDB-GENE-040204-1
- Name
- malate dehydrogenase 1Aa, NAD (soluble)
- Symbol
- mdh1aa Nomenclature History
- Previous Names
-
- mdh1a
- MDH1b (1)
- fj05b08
- wu:fj05b08
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable L-malate dehydrogenase (NAD+) activity. Predicted to be involved in NAD+ metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; integument; mesoderm; pectoral fin; and sensory system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 88. Orthologous to human MDH1 (malate dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63941 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 88 | Alliance | ?Developmental and epileptic encephalopathy 88 | 618959 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001252 | Malate dehydrogenase, active site |
| Domain | IPR001236 | Lactate/malate dehydrogenase, N-terminal |
| Domain | IPR022383 | Lactate/malate dehydrogenase, C-terminal |
| Family | IPR001557 | L-lactate/malate dehydrogenase |
| Family | IPR010945 | Malate dehydrogenase, type 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal | Lactate/malate dehydrogenase, C-terminal | Lactate/malate dehydrogenase, N-terminal | L-lactate/malate dehydrogenase | Malate dehydrogenase, active site | Malate dehydrogenase, NAD-dependent, cytosolic | Malate dehydrogenase, type 2 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3D9 | InterPro | 305 | ||||||||
| UniProtKB:A0A2R9YJL1 | InterPro | 350 | ||||||||
| UniProtKB:Q801E6 | InterPro | 333 | ||||||||
| UniProtKB:A0A8M1P861 | InterPro | 354 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mdh1aa-201
(1)
|
Ensembl | 1,714 nt | ||
| mRNA |
mdh1aa-202
(1)
|
Ensembl | 1,472 nt | ||
| mRNA |
mdh1aa-204
(1)
|
Ensembl | 507 nt | ||
| mRNA |
mdh1aa-205
(1)
|
Ensembl | 363 nt | ||
| mRNA |
mdh1aa-206
(1)
|
Ensembl | 689 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-233A22 | ZFIN Curated Data | |
| Contained in | BAC | CH73-384K13 | ZFIN Curated Data | |
| Contains | STS | chunp30292 | ||
| Encodes | EST | fj05b08 | ||
| Encodes | EST | fq38b12 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:63941 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309523 (1) | 1726 nt | ||
| Genomic | GenBank:CU651563 (2) | 99177 nt | ||
| Polypeptide | UniProtKB:A0A8M1P861 (1) | 354 aa |
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Kim, Y.I., Nam, I.K., Lee, D.K., Bhandari, S., Charton, L., Kwak, S., Lim, J.Y., Hong, K., Kim, S.J., Lee, J.N., Kwon, S.W., So, H.S., Linka, N., Park, R., Choe, S.K. (2019) Slc25a17 acts as a peroxisomal coenzyme A transporter and regulates multiorgan development in zebrafish. Journal of Cellular Physiology. 235(1):151-165
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
- Higdon, C.W., Mitra, R.D., and Johnson, S.L. (2013) Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS One. 8(7):e67801
- Singh, S.K., Saxena, S., Lakshmi, M.G., Saxena, P., and Idris, M.M. (2011) Proteome Profile of Zebrafish Danio rerio Olfactory Bulb Based on Two-Dimensional Gel Electrophoresis Matrix-Assisted Laser Desorption/Ionization MS/MS Analysis. Zebrafish. 8(4):183-189
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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