ZFIN is now using GRCz12tu for Genomic Data
Gene
eif4a1b
- ID
- ZDB-GENE-040120-6
- Name
- eukaryotic translation initiation factor 4A1B
- Symbol
- eif4a1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Is expressed in immature eye; lens; and somite. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56410 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024894Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000629 | ATP-dependent RNA helicase DEAD-box, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR014014 | RNA helicase, DEAD-box type, Q motif |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent RNA helicase DEAD-box, conserved site | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | DEAD/DEAH box helicase domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | RNA helicase, DEAD-box type, Q motif |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU67 | InterPro | 406 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif4a1b-201
(1)
|
Ensembl | 2,241 nt | ||
| ncRNA |
eif4a1b-002
(1)
|
Ensembl | 780 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-137I24 | ZFIN Curated Data | |
| Encodes | EST | fb54c08 | ||
| Encodes | cDNA | MGC:56410 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174169 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201510 (1) | 2234 nt | ||
| Genomic | GenBank:BX119902 (1) | 170241 nt | ||
| Polypeptide | UniProtKB:Q7ZU67 (1) | 406 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Torraca, V., Tulotta, C., Snaar-Jagalska, B.E., Meijer, A.H. (2017) The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Scientific Reports. 7:45061
- Benard, E.L., Racz, P.I., Rougeot, J., Nezhinsky, A.E., Verbeek, F.J., Spaink, H.P., Meijer, A.H. (2015) Macrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish. Journal of Innate Immunity. 7(2):136-52
- Fink, I.R., Benard, E.L., Hermsen, T., Meijer, A.H., Forlenza, M., Wiegertjes, G.F. (2015) Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Molecular immunology. 63(2):381-93
- Torraca, V., Cui, C., Boland, R., Bebelman, J.P., van der Sar, A.M., Smit, M.J., Siderius, M., Spaink, H.P., Meijer, A.H. (2015) The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease models & mechanisms. 8(3):253-69
- Benard, E.L., Roobol, S.J., Spaink, H.P., Meijer, A.H. (2014) Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and comparative immunology. 47(2):223-33
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
- Rösel, T.D., Hung, L.H., Medenbach, J., Donde, K., Starke, S., Benes, V., Rätsch, G., and Bindereif, A. (2011) RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. The EMBO journal. 30(10):1965-1976
- De Wit, M., Keil, D., van der Ven, K., Vandamme, S., Witters, E., and De Coen, W. (2010) An integrated transcriptomic and proteomic approach characterising estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). General and comparative endocrinology. 167(2):190-201
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