gfi1ab

ID

ZDB-GENE-040116-8

Name

growth factor independent 1A transcription repressor b

Symbol

gfi1ab Nomenclature History

Previous Names

gfi1.2
gfi1
gfi1b

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hair cell differentiation and peripheral nervous system development. Is expressed in anterior lateral mesoderm; nervous system; otic vesicle; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

36 figures from 22 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Yu et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gfi1ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
severe congenital neutropenia 2	Alliance	Neutropenia, severe congenital 2, autosomal dominant	613107
		?Neutropenia, nonimmune chronic idiopathic, of adults	607847

Associated With gfi1ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR050717	C2H2-type Zinc-Finger Transcription Regulators
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily