ZFIN is now using GRCz12tu for Genomic Data
Gene
insb
- ID
- ZDB-GENE-040113-2
- Name
- preproinsulin b
- Symbol
- insb Nomenclature History
- Previous Names
-
- zfins2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable hormone activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Is expressed in several structures, including blastomere; dermal bone; digestive system; kidney; and shield. Human ortholog(s) of this gene implicated in several diseases, including diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; lung disease (multiple); and sleep apnea. Orthologous to several human genes including INS (insulin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin | Insulin, conserved site | Insulin/IGF/relaxin | Insulin-like | Insulin-like superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A140LFX1 | InterPro | 151 | |||||
| UniProtKB:A0A8M6Z2M5 | InterPro | 167 | |||||
| UniProtKB:Q2QAJ9 | InterPro | 107 | |||||
| UniProtKB:A0AB32T7F9 | InterPro | 159 | |||||
| UniProtKB:A0AC58H6M5 | InterPro | 159 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers