Gene

chrnb3a

ID
ZDB-GENE-040108-1
Name
cholinergic receptor nicotinic beta 3 subunit a
Symbol
chrnb3a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zirger et al., 2003
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa12587Allele with one point mutationUnknownPremature StopENU
sa39605Allele with one point mutationUnknownPremature StopENU
zko424aAllele with one deletionUnknownUnknownCRISPR
zko424bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-chrnb3a (2)
CRISPR2-chrnb3a (2)
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Human Disease
Associated With chrnb3a Human Ortholog
No data available
Associated With chrnb3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
Family IPR002394 Nicotinic acetylcholine receptor
Family IPR006201 Neurotransmitter-gated ion-channel
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Domain Details Per Protein
Protein Additional Resources Length Neuronal acetylcholine receptor Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily Nicotinic acetylcholine receptor
UniProtKB:Q7ZZP6 InterPro 467
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA chrnb3a-201 (1) Ensembl 2,128 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-380N15ZFIN Curated Data
Contained inBACDKEY-234D14ZFIN Curated Data
ContainsSTSchunp6849
    Zirger et al., 2003
    EncodescDNAMGC:193626ZFIN Curated Data
    EncodescDNAMGC:193636ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanCHRNB38
    Amino acid sequence comparison (1)
    Phylogenetic tree (1)
    Conserved genome location (synteny) (1)
    MouseChrnb38
    Amino acid sequence comparison (1)
    Phylogenetic tree (1)
    Citations
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