Gene
fosab
- ID
- ZDB-GENE-031222-4
- Name
- v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
- Symbol
- fosab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Contributes to double-stranded DNA binding activity. Acts upstream of or within cardiac muscle tissue regeneration; hematopoietic stem cell differentiation; and multicellular organismal response to stress. Predicted to be active in nucleus. Is expressed in several structures, including epidermis; head; hematopoietic system; nervous system; and pronephric duct. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 107 figures from 84 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1065 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Maili et al., 2023
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fosab | Maili et al., 2023 | |
| CRISPR2-fosab | Maili et al., 2023 | |
| CRISPR3-fosab | Wang et al., 2025 | |
| CRISPR4-fosab | Wang et al., 2025 | |
| CRISPR5-fosab | Huang et al., 2025 | |
| MO1-fosab | N/A | Wei et al., 2014 |
| MO2-fosab | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AP-1 transcription factor | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6P0S4 | InterPro | 349 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Et(fos:GAL4-VP16) |
|
| 129 | (29) | |
| Et(en2a-fosab:EGFP-CAAX) |
|
| 1 | (2) | |
| Et(fos:KALTA4,5xUAS:NTR,14xUAS:GAP-YFP) |
|
| 2 | (3) | |
| Tg(5xHsa.ATF6-fosab:d2EGFP) |
|
| 1 | (3) | |
| Tg(5xHsa.ATF6-fosab:EGFP) |
|
| 1 | (2) | |
| Tg(en.cen-fosab:EGFP) |
|
| 2 | Sun et al., 2022 | |
| Tg(Hsa.C2CD4Ars7163757-fosab:EGFP) |
|
| 1 | Mousavy Gharavy et al., 2021 | |
| Tg(ubb:LOXP-EGFP-LOXP-2A-FLAG-dnfosab-2A-TagBFP-HA) |
| 1 | Beisaw et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-153J24 | ZFIN Curated Data | |
| Encodes | EST | cb1065 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:77885 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205569 (1) | 1706 nt | ||
| Genomic | GenBank:AL929435 (1) | 181400 nt | ||
| Polypeptide | UniProtKB:Q6P0S4 (1) | 349 aa |
- Dogra, D., Phan, V.A., Zhang, S., Gavrilovici, C., DiMarzo, N., Narang, A., Ibhazehiebo, K., Kurrasch, D.M. (2025) Modulation of NMDA receptor signaling and zinc chelation prevent seizure-like events in a zebrafish model of SLC13A5 epilepsy. PLoS Biology. 23:e3002499e3002499
- Fernández, J.A.A., de Moura, T.C., Vila, S.F., Gaytán, J.A.R., López-Díaz, I., Learte-Aymamí, S., Vázquez, M.E., Mayán, M.D., Sánchez, L., Maurer-Morelli, C.V. (2025) Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish. PLoS One. 20:e0308581e0308581
- Huang, D., Kapadia, E.H., Liang, Y., Shriver, L.P., Dai, S., Patti, G.J., Humbel, B.M., Laudet, V., Parichy, D.M. (2025) Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 122:e2424180122e2424180122
- Li, J., Zhou, Z., Feng, F., Yuan, W., Zhang, Y., Wang, J., Zhang, B., Jin, H., He, S., Ding, L. (2025) Three New α-Pyrone Derivatives with Antiepileptic Activity from the Marine Actinomycete Nocardiopsis sp. NBUDK19. Marine biotechnology (New York, N.Y.). 27:8585
- Li, X., Gao, X., Liu, S., Liu, S., Liu, Y., Gao, L., Xia, L., Liu, K., Jin, M. (2025) 2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2 + inward flow and microglial activation. Ecotoxicology and environmental safety. 295:118154118154
- Wang, Q., Zhang, L., Zhu, C., Lu, K., Wu, J., Liang, X.F. (2025) Fosab, but not fosaa, plays important role in learning and memory in fish-insights from zebrafish gene knockout study. Frontiers in cell and developmental biology. 13:15030661503066
- Camussi, D., Naef, V., Brogi, L., Della Vecchia, S., Marchese, M., Nicoletti, F., Santorelli, F.M., Licitra, R. (2024) Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models. Cells. 13(16):
- Collier, A.D., Yasmin, N., Karatayev, O., Abdulai, A.R., Yu, B., Fam, M., Campbell, S., Leibowitz, S.F. (2024) Embryonic ethanol exposure and optogenetic activation of hypocretin neurons stimulate similar behaviors early in life associated with later alcohol consumption. Scientific Reports. 14:30213021
- Hosaka, S., Hosokawa, M., Hibi, M., Shimizu, T. (2024) The zebrafish cerebellar neural circuits are involved in orienting behavior. eNeuro. 11(10):
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
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