Gene
gja3
- ID
- ZDB-GENE-031217-3
- Name
- gap junction protein, alpha 3
- Symbol
- gja3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables gap junction hemi-channel activity. Acts upstream of or within several processes, including cardiac muscle tissue development; cell communication by electrical coupling; and post-embryonic eye morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of connexin complex. Is expressed in several structures, including kidney; liver; pericardial region; retina; and spinal cord. Human ortholog(s) of this gene implicated in cataract 14 multiple types. Orthologous to human GJA3 (gap junction protein alpha 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cataract 14 multiple types | Alliance | Cataract 14, multiple types | 601885 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Connexin | Connexin, conserved site | Connexin, C-terminal | Connexin, N-terminal | Connexin, N-terminal domain superfamily | Gap junction alpha-5 protein (Cx40), C-terminal | Gap junction protein, cysteine-rich domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JFD2 | InterPro | 434 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-51D17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195070 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195085 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207642 (1) | 1305 nt | ||
| Genomic | GenBank:CR392366 (1) | 125898 nt | ||
| Polypeptide | UniProtKB:Q8JFD2 (1) | 434 aa |
- Liu, J., Li, W., Jin, X., Lin, F., Han, J., Zhang, Y. (2023) Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish. Communications biology. 6:13001300
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Mikalsen, S.O., Tausen, M., Í Kongsstovu, S. (2020) Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. BMC Genomics. 21:223
- Retamal, M.A., Orellana, V.P., Arévalo, N.J., Rojas, C.G., Arjona, R.J., Alcaíno, C.A., González, W., Canan, J.G., Moraga-Amaro, R., Stehberg, J., Reuss, L., Altenberg, G.A. (2019) Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. Nitric oxide : biology and chemistry. 86:54-62
- Usui, Y., Aramaki, T., Kondo, S., Watanabe, M. (2019) The minimal gap-junction network among melanophores and xanthophores required for stripe-pattern formation in zebrafish. Development (Cambridge, England). 146(22):
- Yoshikawa, S., Vila, A., Segelken, J., Lin, Y.P., Mitchell, C.K., Nguyen, D., O'Brien, J. (2017) Zebrafish Connexin 79.8 (Gja8a): A lens connexin used as an electrical synapse in some neurons. Developmental Neurobiology. 77(5):548-561
- Watanabe, M., Sawada, R., Aramaki, T., Skerrett, I.M., Kondo, S. (2016) The physiological characterization of Connexin41.8 and Connexin39.4, which are involved in the stripe pattern formation of zebrafish. The Journal of biological chemistry. 291(3):1053-63
- Ye, L., Robertson, M.A., Mastracci, T.L., Anderson, R.M. (2016) An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration. Developmental Biology. 409(2):354-69
- Ye, L., Robertson, M.A., Hesselson, D., Stainier, D.Y., Anderson, R.M. (2015) glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis. Development (Cambridge, England). 142:1407-17
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