ZFIN is now using GRCz12tu for Genomic Data
Gene
traf3ip2b
- ID
- ZDB-GENE-031118-74
- Name
- TRAF3 interacting protein 2b
- Symbol
- traf3ip2b Nomenclature History
- Previous Names
-
- act1 (1)
- traf3ip2
- fn06a08
- wu:fn06a08
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables ubiquitin protein ligase binding activity. Acts upstream of or within defense response to virus. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2).
- Genome Resources
-
- Alliance (1)
- Gene:386940 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chronic mucocutaneous candidiasis | Alliance | ?Candidiasis, familial, 8 | 615527 |
| psoriasis 13 | Alliance | {Psoriasis susceptibility 13} | 614070 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin ligase TRAF3IP2 | SEFIR domain |
|---|---|---|---|---|
| UniProtKB:A0A8M9PVR8 | InterPro | 368 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073917178 (1) | GRCz12tu | 3284 nt | |
| Genomic | GenBank:FO704721 (1) | 103274 nt | ||
| Polypeptide | UniProtKB:A0A8M9PVR8 (1) | 368 aa |
- Comparative Orthology
- Alliance
- Ryzhakov, G., Blazek, K., Lai, C.C., and Udalova, I.A. (2012) IL-17 Receptor Adaptor Protein Act1/CIKS Plays an Evolutionarily Conserved Role in Antiviral Signaling. Journal of immunology (Baltimore, Md. : 1950). 189(10):4852-4858
- Ryzhakov, G., Blazek, K., and Udalova, I.A. (2011) Evolution of Vertebrate Immunity: Sequence and Functional Analysis of the SEFIR Domain Family Member Act1. Journal of molecular evolution. 72(5-6):521-30
- Hart, D.O., Raha, T., Lawson, N.D., and Green, M.R. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature. 450(7172):1082-1085
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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