ZFIN is now using GRCz12tu for Genomic Data
Gene
bicra
- ID
- ZDB-GENE-031116-2
- Name
- BRD4 interacting chromatin remodeling complex associated protein
- Symbol
- bicra Nomenclature History
- Previous Names
-
- gltscr1
- sb:cb888
- si:dkey-224e22.6
- wu:fc28g11
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within embryonic cranial skeleton morphogenesis. Predicted to be part of SWI/SNF complex. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; midbrain neural keel; nervous system; and presumptive telencephalon. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 12. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb888 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Barish et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1404 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| sa13301 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16525 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23374 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29089 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36722 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43165 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Coffin-Siris syndrome 12 | Alliance | Coffin-Siris syndrome 12 | 619325 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chromatin-remodeling and transcription coactivator | GLTSCR protein, conserved domain |
|---|---|---|---|---|
| UniProtKB:A0A8M2B5V9 | InterPro | 1823 | ||
| UniProtKB:A0A8M1QHS7 | InterPro | 1801 | ||
| UniProtKB:A0A8M2B5S5 | InterPro | 1822 | ||
| UniProtKB:A0A8M2B5S4 | InterPro | 1761 | ||
| UniProtKB:A0AB32T7L6 | InterPro | 1800 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-224E22 | ZFIN Curated Data | |
| Encodes | EST | cb888 | Thisse et al., 2001 | |
| Encodes | EST | fc28g11 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005159252 (1) | GRCz12tu | 6574 nt | |
| Genomic | GenBank:BX936429 (1) | 158832 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5V9 (1) | 1823 aa |
- Barish, S., Barakat, T.S., Michel, B.C., Mashtalir, N., Phillips, J.B., Valencia, A.M., Ugur, B., Wegner, J., Scott, T.M., Bostwick, B., Undiagnosed Diseases Network, Murdock, D.R., Dai, H., Perenthaler, E., Nikoncuk, A., van Slegtenhorst, M., Brooks, A.S., Keren, B., Nava, C., Mignot, C., Douglas, J., Rodan, L., Nowak, C., Ellard, S., Stals, K., Lynch, S.A., Faoucher, M., Lesca, G., Edery, P., Engleman, K.L., Zhou, D., Thiffault, I., Herriges, J., Gass, J., Louie, R.J., Stolerman, E., Washington, C., Vetrini, F., Otsubo, A., Pratt, V.M., Conboy, E., Treat, K., Shannon, N., Camacho, J., Wakeling, E., Yuan, B., Chen, C.A., Rosenfeld, J.A., Westerfield, M., Wangler, M., Yamamoto, S., Kadoch, C., Scott, D.A., Bellen, H.J. (2020) BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. American journal of human genetics. 107(6):1096-1112
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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