Gene

dnaaf1

ID
ZDB-GENE-031114-4
Name
dynein axonemal assembly factor 1
Symbol
dnaaf1 Nomenclature History
Previous Names
  • loc123872 (1)
  • lrrc50
  • switch hitter (1)
  • swt (1)
  • unm tm317b
  • zgc:56169
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Enables dynein complex binding activity. Acts upstream of or within several processes, including axoneme assembly; convergent extension involved in gastrulation; and embryonic heart tube development. Predicted to be located in axoneme. Is expressed in several structures, including chordo neural hinge; forerunner cell group; intermediate mesoderm; nervous system; and pronephric duct. Used to study autosomal dominant polycystic kidney disease; seminoma; and testicular germ cell cancer. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
29 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnaaf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ciliary dyskinesia 13 Alliance Ciliary dyskinesia, primary, 13 613193
Associated With dnaaf1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR027734 Dynein assembly factor 1, axonemal
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length Dynein assembly factor 1, axonemal Leucine-rich repeat Leucine-rich repeat domain superfamily
UniProtKB:A0A1D5NSQ8 147
UniProtKB:F1Q654 562
UniProtKB:A0A1D5NS57 66
UniProtKB:Q7ZV84 555
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations