Gene
sox8b
- ID
- ZDB-GENE-031114-1
- Name
- SRY-box transcription factor 8b
- Symbol
- sox8b Nomenclature History
- Previous Names
-
- sox8
- zgc:109880
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in morphogenesis of an epithelium; negative regulation of transcription by RNA polymerase II; and neural crest cell development. Predicted to be active in nucleus. Is expressed in oocyte; pharyngeal arch; and trunk neural crest. Orthologous to human SOX8 (SRY-box transcription factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | Sox developmental protein N-terminal | SOX Transcription Factors |
|---|---|---|---|---|---|---|
| UniProtKB:Q52W08 | InterPro | 358 | ||||
| UniProtKB:A0A8M1N736 | InterPro | 356 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-225N18 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-384E4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109880 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025465 (1) | 1875 nt | ||
| Genomic | GenBank:BX470259 (2) | 188687 nt | ||
| Polypeptide | UniProtKB:Q52W08 (1) | 358 aa |
- Jackson, A., Lin, S.J., Jones, E.A., Chandler, K.E., Orr, D., Moss, C., Haider, Z., Ryan, G., Holden, S., Harrison, M., Burrows, N., Jones, W.D., Loveless, M., Petree, C., Stewart, H., Low, K., Donnelly, D., Lovell, S., Drosou, K., Genomics England Research Consortium, Solve-RD consortium, Varshney, G.K., Banka, S. (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. HGG advances. 4:100186100186
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Zafar, I., Iftikhar, R., Ahmad, S.U., Rather, M.A. (2021) Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Biotechnology reports (Amsterdam, Netherlands). 30:e00607
- Martik, M.L., Gandhi, S., Uy, B.R., Gillis, J.A., Green, S.A., Simoes-Costa, M., Bronner, M.E. (2019) Evolution of the new head by gradual acquisition of neural crest regulatory circuits. Nature. 574(7780):675-678
- Lee, E.M., Yuan, T., Ballim, R.D., Nguyen, K., Kelsh, R.N., Medeiros, D.M., McCauley, D.W. (2016) Functional constraints on SoxE proteins in neural crest development: the importance of differential expression for evolution of protein activity. Developmental Biology. 418(1):166-78
- Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73
- Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q., Liang, X., Liu, K., Zhang, L., Lu, T., Huang, T., Fan, D., Weng, Q., Zhu, C., Lu, Y., Li, W., Wen, Z., Zhou, C., Tian, Q., Kang, X., Shi, M., Zhang, W., Jang, S., Du, F., He, S., Liao, L., Li, Y., Gui, B., He, H., Ning, Z., Yang, C., He, L., Luo, L., Yang, R., Luo, Q., Liu, X., Li, S., Huang, W., Xiao, L., Lin, H., Han, B., Zhu, Z. (2015) The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics. 47(6):625-31
- Hofsteen, P., Plavicki, J., Johnson, S.D., Peterson, R.E., and Heideman, W. (2013) Sox9b is Required for Epicardium Formation and Plays a Role in TCDD-induced Heart Malformation in Zebrafish. Molecular pharmacology. 84(3):353-60
- Juarez, M., Reyes, M., Coleman, T., Rotenstein, L., Sao, S., Martinez, D., Jones, M., Mackelprang, R., and de Bellard, M.E. (2013) Characterization of the trunk neural crest in the bamboo shark, Chiloscyllium punctatum. The Journal of comparative neurology. 521(14):3303-20
- Dalcq, J., Pasque, V., Ghaye, A., Larbuisson, A., Motte, P., Martial, J.A., and Muller, M. (2012) RUNX3, EGR1 and SOX9B Form a Regulatory Cascade Required to Modulate BMP-Signaling during Cranial Cartilage Development in Zebrafish. PLoS One. 7(11):e50140
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