Gene
lhx8a
- ID
- ZDB-GENE-031008-2
- Name
- LIM homeobox 8a
- Symbol
- lhx8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in forebrain neuron development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; dental mesenchyme; pharyngeal arch 1; and pharynx. Orthologous to human LHX8 (LIM homeobox 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb875 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014804Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa180 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18198 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18505 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BIF2 | InterPro | 328 | |||||
| UniProtKB:Q6BDC3 | InterPro | 332 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-189N19 | ZFIN Curated Data | |
| Encodes | EST | cb875 | Thisse et al., 2001 | |
| Encodes | EST | fk78g12 | ||
| Encodes | cDNA | MGC:136448 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003980 (1) | 1508 nt | ||
| Genomic | GenBank:BX901918 (2) | 171438 nt | ||
| Polypeptide | UniProtKB:Q6BDC3 (1) | 332 aa |