Gene
disp2
- ID
- ZDB-GENE-030915-1
- Name
- dispatched RND transporter family member 2
- Symbol
- disp2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Acts upstream of or within miRNA-mediated post-transcriptional gene silencing. Predicted to be active in membrane. Orthologous to human DISP2 (dispatched RND transporter family member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Li et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dispatched hedgehog regulator | Sterol-sensing domain |
|---|---|---|---|---|
| UniProtKB:Q6R5J1 | InterPro | 1476 | ||
| UniProtKB:A0A8M2B5N9 | InterPro | 1477 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-9A1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212434 (1) | 4581 nt | ||
| Genomic | GenBank:BX571712 (1) | 118076 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5N9 (1) | 1477 aa |
- Kaur, S., Gupta, S., Chaudhary, M., Khursheed, M.A., Mitra, S., Kurup, A.J., Ramachandran, R. (2018) let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration. Cell Reports. 23:1409-1423
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Li, N., Flynt, A.S., Kim, H.R., Solnica-Krezel, L., and Patton, J.G. (2008) Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic acids research. 36(13):4277-4285
- Lagerstrom, M.C., Fredriksson, R., Bjarnadottir, T.K., Fridmanis, D., Holmquist, T., Andersson, J., Yan, Y.L., Raudsepp, T., Zoorob, R., Kukkonen, J.P., Lundin, L.G., Klovins, J., Chowdhary, B.P., Postlethwait, J.H., and Schioth, H.B. (2005) Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution. Genomics. 85(6):688-703
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F., and Ingham, P.W. (2004) Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Developmental Biology. 269(2):381-392
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