ZFIN is now using GRCz12tu for Genomic Data
Gene
grem2b
- ID
- ZDB-GENE-030911-9
- Name
- gremlin 2, DAN family BMP antagonist b
- Symbol
- grem2b Nomenclature History
- Previous Names
-
- grem2
- prdc (1)
- zgc:112207
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable BMP binding activity and receptor ligand activity. Acts upstream of or within cardiac atrium development and cartilage morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; optic cup; optic vesicle; and swim bladder bud. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Tooth agenesis, selective, 9 | 617275 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine knot, C-terminal | Cystine-knot cytokine | DAN | Gremlin-1/2 |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AYP8 | InterPro | 222 | ||||
| UniProtKB:Q566Z5 | InterPro | 166 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grem2b-201
(1)
|
Ensembl | 866 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers